{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:58:02Z","timestamp":1789923482311,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31101264; 31401489"],"award-info":[{"award-number":["NSFC31101264; 31401489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161376"],"award-info":[{"award-number":["BK20161376"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In\u00a0recent\u00a0years, the\u00a0blueberry\u00a0cultivation\u00a0and\u00a0processing industry\u00a0developed quickly because blueberries are super\u2010fruit with healthy function. Blueberry leaves are byproducts of the blueberry industry, which are rich in bioactive phenolics, such as quercetin (Q), hyperin (H), and chlorogenic acid (C). This study investigated protective effects of 3 phenolics (Q, H, and C) from leaves of rabbiteye blueberry\n                    <jats:italic>Vaccinium ashei<\/jats:italic>\n                    on human umbilical vein endothelial cells. The results showed that all these 3 phenolics could improve endothelial function by inhibiting oxidative damage and proinflammatory cytokines caused by tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1). The cell vitalities of endothelial cells pretreated with Q, H, and C were higher than those stimulated with TNF\u2010\u03b1 only. These phenolics could decrease reactive oxygen species and xanthine oxidase\u20101 levels and increase superoxide dismutase and heme oxygenase\u20101 levels in endothelial cells. They also could decrease the protein expressions of intercellular adhesion molecule\u20101, vascular cell adhesion molecule\u20101, and monocyte chemotactic protein\u20101 induced by TNF\u2010\u03b1. In addition, Q, H, and C also exhibited vasodilatory effect by reducing the angiotensin I\u2013converting enzyme (ACE) protein levels in endothelial cells. Mostly 3 phenolics exhibited bioactivities as a function of concentration, but the effects not always depended on the concentration. The antioxidant and antiinflammatory effects of Q seemed to be more pronounced than H; however, H exhibited higher cell vitalities. The results indicated that phenolics from rabbiteye blueberry leaves could be potential antioxidants, inflammation and ACE inhibitors, and rabbiteye blueberry leaves provide a new resources of phytochemicals beneficial for cardiovascular health.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.13706","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T14:35:50Z","timestamp":1492094150000},"page":"1239-1246","source":"Crossref","is-referenced-by-count":63,"title":["Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects"],"prefix":"10.1111","volume":"82","author":[{"given":"Wu\u2010Yang","family":"Huang","sequence":"first","affiliation":[{"name":"Inst. of Farm Product Processing Jiangsu Academy of Agricultural Sciences  Nanjing Jiangsu PR China"},{"name":"Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement  Nanjing Jiangsu PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[{"name":"Inst. of Farm Product Processing Jiangsu Academy of Agricultural Sciences  Nanjing Jiangsu PR China"},{"name":"College of Food Engineering Harbin Univ. Of Commerce  Songbei Qu Haerbin Shi Heilongjiang Sheng PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Inst. of Farm Product Processing Jiangsu Academy of Agricultural Sciences  Nanjing Jiangsu PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Engineering Harbin Univ. Of Commerce  Songbei Qu Haerbin Shi Heilongjiang Sheng PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Inst. of Farm Product Processing Jiangsu Academy of Agricultural Sciences  Nanjing Jiangsu PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science Hainan Univ.  Haikou PR 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