{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:47:07Z","timestamp":1790786827520,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:00:00Z","timestamp":1495843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Ocean University Strong School Innovation Fund Project","award":["Q14202"],"award-info":[{"award-number":["Q14202"]}]},{"name":"Disciplinary Construction Project of Institutions of Higher Learning in Guangdong Province","award":["2013CXZDA020"],"award-info":[{"award-number":["2013CXZDA020"]}]},{"name":"Industry-University Research Cooperation Project in Guangdong Province","award":["2013B090600155"],"award-info":[{"award-number":["2013B090600155"]}]},{"name":"Modern Agro-industry Technology Research System of China","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inhibition of dipeptidyl peptidase IV (DPP\u2010IV) and angiotensin converting enzyme (ACE) are considered useful in managing 2 often associated conditions: diabetes and hypertension. In this study, corolase PP was used to hydrolyze Antarctic krill protein. The hydrolysate (AKH) was isolated by ultrafiltration and purified by size\u2010exclusion chromatography, ion exchange chromatography and reversed\u2010phase high\u2010performance liquid chromatography (RP\u2010HPLC) sequentially. The in vitro inhibitory activities of all AKHs and several fractions obtained against ACE and DPP\u2010IV were assessed. Two peptides, purified with dual\u2010strength inhibitory activity against ACE and DPP\u2010IV, were identified by TOF\u2010MS\/MS. Results indicated that not all fractions exhibited dual inhibitory activities of ACE and DPP\u2010IV. The purified peptide Lys\u2010Val\u2010Glu\u2010Pro\u2010Leu\u2010Pro had half\u2010maximal inhibitory concentrations (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 0.93\u00b10.05 and 0.73\u00b10.04 mg\/mL against ACE and DPP\u2010IV, respectively. The other peptide Pro\u2010Ala\u2010Leu had IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.64\u00b10.05 and 0.88\u00b10.03 mg\/mL against ACE and DPP\u2010IV, respectively. This study firstly reported the sequences of dual bioactive peptides from Antarctic krill proteins, further provided new insights into the bioactive peptides responsible for the ACE and DPP\u2010IV inhibitory activities from the Antarctic krill protein hydrolysate to manage hypertension and diabetes.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.13735","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T05:52:46Z","timestamp":1495864366000},"page":"1742-1749","source":"Crossref","is-referenced-by-count":49,"title":["Two Novel Bioactive Peptides from Antarctic Krill with Dual Angiotensin Converting Enzyme and Dipeptidyl Peptidase IV Inhibitory Activities"],"prefix":"10.1111","volume":"82","author":[{"given":"Wei","family":"Ji","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Guangdong Ocean Univ.  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Guangdong Ocean Univ.  Zhanjiang China"},{"name":"Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety  Zhanjiang China"},{"name":"Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Inst.  Zhanjiang China"},{"name":"South China Sea Bio\u2010Resource Exploitation and Utilization Collaborative Innovation Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Guangdong Ocean Univ.  Zhanjiang China"},{"name":"Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety  Zhanjiang China"},{"name":"Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Inst.  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0703"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.07.076"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13177"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0227-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.01026.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1965.tb02091.x"},{"key":"e_1_2_7_8_1","volume-title":"Global brief on hypertension","year":"2013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.04.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421301"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.09.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.183"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.03.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13508"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2009.01138.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.09.083"},{"key":"e_1_2_7_17_1","unstructured":"International Diabetes Federation.2015.IDF diabetes atlas 7th ed. 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