{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:39:10Z","timestamp":1768437550358,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol\u2010induced developmental defect using zebrafish as a model was determined. Ethanol\u2010induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol\u2010induced defects. Curcuminoid content of the turmeric powder extract (5 mg\/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124.1 \u00b1 0.2 \u03bcg\/mL), Desmethoxycurcumin (43.4 \u00b1 0.1 \u03bcg\/mL), and Bisdemethoxycurcumin (36.6 \u00b1 0.1 \u03bcg\/mL). Zebrafish embryos were treated with 100 mM (0.6% v\/v) ethanol during gastrulation through organogenesis (2 to 48 h postfertilization (hpf)) and supplemented with turmeric extract to obtain total curcuminoid concentrations of 0, 1.16, 1.72, or 2.32 \u03bcM. Turmeric supplementation showed significant rescue of the body length at 72 hpf compared to ethanol\u2010treated embryos. The mechanism underlying the rescue remains to be determined.<\/jats:p>","DOI":"10.1111\/1750-3841.13830","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T07:52:44Z","timestamp":1502351564000},"page":"2221-2225","source":"Crossref","is-referenced-by-count":10,"title":["Turmeric Extract Rescues Ethanol\u2010Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)"],"prefix":"10.1111","volume":"82","author":[{"given":"Pooja","family":"Muralidharan","sequence":"first","affiliation":[{"name":"Dept. of Biology Indiana Univ.\u2010Purdue Univ. Indianapolis  Indianapolis Ind. 46202 U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig T.","family":"Connors","sequence":"additional","affiliation":[{"name":"Dept. of Biology Indiana Univ.\u2010Purdue Univ. 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