{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:20:48Z","timestamp":1790814048041,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["Grand No. 103\u20102221\u2010E415\u2010\u2010015"],"award-info":[{"award-number":["Grand No. 103\u20102221\u2010E415\u2010\u2010015"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cold water extract of\n                    <jats:italic>P. citrinopileatus<\/jats:italic>\n                    (CWEPC) was fractioned into 4 fractions, PC\u2010I (&lt;1 kDa), PC\u2010II (1\u20103.5 kDa), PC\u2010III (3.5\u201010 kDa), and PC\u2010IV (&gt;10 kDa), by ultrafiltration. The antioxidant activities, the inhibition of pancreatic \u03b1\u2010amylase, intestinal \u03b1\u2010glucosidase, and hypertension\u2010linked angiotensin converting enzyme (ACE), as well as the contents of polysaccharides, protein, and phenolic compounds of 4 fractions were determined. The results showed that lower MW fractions exerted a higher antioxidant activity, which was correlated to phenolic contents. The high molecular fraction (PC\u2010IV) exhibited significantly higher inhibitory activity on \u03b1\u2010amylase, \u03b1\u2010glucosidase, and ACE compared to CWEPC and the other 3 lower MW fractions (&lt;10 kDa), which was more related to protein contents. The inhibition capability of CWEPC and PC\u2010IV on \u03b1\u2010amylase activity was 1\/13.4 to 1\/2.7 relative to that of acarbose, respectively. Kinetic data revealed that PC\u2010IV fraction followed a noncompetitive inhibition pattern on \u03b1\u2010glucosidase activity. The study demonstrated that various MW fractions and types of components contribute to different biological functions of\n                    <jats:italic>P. citrinopileatus<\/jats:italic>\n                    and it is protein constituents but not peptides responsible for the hypoglycemic potential of CWEPC.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.13851","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T11:33:10Z","timestamp":1504006390000},"page":"2456-2461","source":"Crossref","is-referenced-by-count":14,"title":["Molecular Weight Affected Antioxidant, Hypoglycemic and Hypotensive Activities of Cold Water Extract from\n                    <i>Pleurotus citrinopileatus<\/i>"],"prefix":"10.1111","volume":"82","author":[{"given":"Pao\u2010Huei","family":"Chen","sequence":"first","affiliation":[{"name":"Dept. of Food Science Natl. Chia\u2010Yi Univ.  Chia\u2010Yi Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Ming","family":"Weng","sequence":"additional","affiliation":[{"name":"Dept. of Food Science Natl. Chia\u2010Yi Univ.  Chia\u2010Yi Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"Dept. of Food Science Natl. Chia\u2010Yi Univ.  Chia\u2010Yi Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zer\u2010Ran","family":"Yu","sequence":"additional","affiliation":[{"name":"Superwell Biotechnology Corp.  Taichung City Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-2250","authenticated-orcid":false,"given":"Be\u2010Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Dept. of Food Science Natl. Chia\u2010Yi Univ.  Chia\u2010Yi Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(00)00324-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780199634491.001.0001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103576r"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901284s"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.02.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(98)00193-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(71)90292-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.02.087"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf052890d"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0043-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushr.v15.i3.30"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/283964"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.njas.2012.03.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2006.04.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01318a036"},{"key":"e_1_2_7_18_1","first-page":"145","article-title":"Anti\u2010diabetic and anti\u2010hypertensive potential of sprouted and solid\u2010state bioprocessed soybean","volume":"14","author":"McCue P","year":"2005","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.12.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(96)00339-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf300569w"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.10.107"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0257"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0225"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.01.130"},{"key":"e_1_2_7_26_1","first-page":"1036","article-title":"Potential of cranberry powder for management of hyperglycemia using in vitro models","volume":"13","author":"Quettier\u2010Deleu C","year":"2000","journal-title":"J Med Food"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9033199"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4114"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2887"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00018a005"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6671"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12686"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2011.11.001"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/AMR.807-809.438"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-004-1833-x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.077"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.11.016"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.13851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.13851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:08:08Z","timestamp":1762178888000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.13851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/1750-3841.13851"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.13851","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}