{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:08:52Z","timestamp":1785380932618,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Argentina-MINCyT and Brazil-CAPES","award":["BR\/09\/14"],"award-info":[{"award-number":["BR\/09\/14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The aim of this study is to evaluate the influence of the technological processing on the functionality of the human breast milk probiotic strain\n                      <jats:italic>Bifidobacterium lactis<\/jats:italic>\n                      INL1.\n                      <jats:italic>In vitro<\/jats:italic>\n                      antagonistic activity of\n                      <jats:italic>B. lactis<\/jats:italic>\n                      INL1 was detected for Gram\u2010positive and Gram\u2010negative pathogens.\n                      <jats:italic>B. lactis<\/jats:italic>\n                      INL1 was administered to mice as fresh (F), frozen (Z), spray\u2010dried (S), or lyophilized (L) culture. Immune parameters (IgA, IL\u201010, and IFN\u2010\u03b3) were determined and histological analysis was performed to assess functionality and protection capacity against\n                      <jats:italic>Salmonella<\/jats:italic>\n                      . In BALB\/c mice, F and S cultures induced an increase in the number of IgA\u2010producing cells in the small intestine and IL\u201010 levels were increased for L culture in the large intestine. In Swiss mice,\n                      <jats:italic>B. lactis<\/jats:italic>\n                      INL1 increased secretory\u2010IgA levels in the small intestine before and after\n                      <jats:italic>Salmonella<\/jats:italic>\n                      infection, both as F or dehydrated culture. Also, an attenuation of damage in the intestinal epithelium and less inflammatory infiltrates were observed in animals that received F and S cultures, whereas in liver only F showed some effect. The anti\u2010inflammatory effect was confirmed in both tissues by myeloperoxidase activity and by IFN\u2010\u03b3 levels in the intestinal content.\n                      <jats:italic>B. lactis<\/jats:italic>\n                      INL1 showed inhibitory activity against pathogens and confirmed its probiotic potential in animal models. Technological processing of the probiotic strain affected its functionality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>This work provides evidence about the influence of technology on the functionality of probiotics, which may help probiotics and functional food manufacturers to take processing into consideration when assessing the functionality of new strains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.13852","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T11:34:50Z","timestamp":1505129690000},"page":"2462-2470","source":"Crossref","is-referenced-by-count":16,"title":["Influence of Technological Treatments on the Functionality of\n                    <i>Bifidobacterium lactis<\/i>\n                    INL1, a Breast Milk\u2010Derived Probiotic"],"prefix":"10.1111","volume":"82","author":[{"given":"Mar\u00eda Florencia","family":"Zacar\u00edas","sequence":"first","affiliation":[{"name":"Inst. de Lactolog\u00eda Industrial (INLAIN) Univ. 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