{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:24:49Z","timestamp":1790738689041,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The antioxidant and anti\u2010inflammatory effects of selenium\u2010enriched yeast (SY) and Gum Arabic (GA) have been reported. This study aimed to determine the hepatoprotective effect of SY and GA combination on carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      )\u2010induced chronic liver injury in rats and to explore their synergistic mechanisms of action. Forty adult male Wistar rats randomly allotted to 5 groups: (A) worked as control, (B) was administered CCl\n                      <jats:sub>4<\/jats:sub>\n                      , (C\u2010E) were fed daily by GA, SY, and GA+SY respectively after mixing with basal diet, following CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010intoxication. GA and SY combination significantly ameliorated CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced reduction in serum total protein with elevation in aspartate transaminase (AST) and alanine transaminase (ALT) in addition to restoring the histopathological changes and hepatic content of hydroxyproline. GA and SY combination was also effective in reducing lipid peroxidation (MDA), consistent with an increase in total antioxidant capacity (T\u2010AOC), glutathione (GSH), superoxide dismutase (SOD) activities, indicating the suppression of liver oxidative stress. Furthermore, liver inflammation was ameliorated by GA and SY combination through inhibition of nuclear factor\u2010kappa (NF\u2010\u03baB), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), cyclooxygenase\u20102(COX\u20102), monocyte\u00a0chemotactic\u00a0protein\u20101 (MCP\u20101), and toll\u2010like receptor 4(TLR\u20104) over expression in the liver. Moreover, the up\u2010regulation of proliferating cell nuclear antigen (PCNA) expression by GA and SY combination enhanced the regeneration of liver tissue after CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010administration. The expression of Collagen1, alpha\u2010smooth muscle actin (\u03b1\u2010SMA), and transforming growth factor\u2010beta1 (TGF\u03b21), was obviously ameliorated by GA and SY combination, suggesting the amelioration of profibrotic response of the liver. Taken together, our current study suggests that GA and SY combination exhibit a significant hepatoprotective activity, which more efficient than GA or SY alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>Chronic liver diseases are the serious health problems, which increase the morbidity and mortality in the world today. Selenium\u2010enriched yeast (SY) and Gum Arabic (GA) combination might be potential dietary agents could obviously ameliorate chronic liver damage, higher than GA and SY alone. They act to suppress the inflammation and inhibit the profibrotic response as well as support the liver regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14030","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T09:08:43Z","timestamp":1516352923000},"page":"525-534","source":"Crossref","is-referenced-by-count":41,"title":["The Hepatoprotective Effect of Selenium\u2010Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride\u2010Induced Chronic Liver Injury in Rats"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-7901","authenticated-orcid":false,"given":"Mohammed","family":"Hamid","sequence":"first","affiliation":[{"name":"Coll. of Veterinary Medicine Nanjing Agricultural Univ.  Jiangsu Province Nanjing 210095 China"},{"name":"Inst. of Nutritional and Metabolic Disorders in Domestic Animals and Fowl Nanjing Agricultural Univ.  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