{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:55:08Z","timestamp":1790430908368,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of obesity. However, limited information is available on how these polyphenols affect the gut microbiota and lipid metabolism. The co\u2010action of a high\u2010fat diet (HFD) and tea polyphenol (TP) on gut microbiota and lipid metabolism using a human flora\u2010associated (HFA) C57BL\/6J mice model is studied. TP reduced serum total cholesterol, triglyceride, low density lipoprotein, glucose (GLU) and insulin (INS) levels of HFD mice in a dose\u2010dependent manner (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). TP also significantly increased acetic acid and butyric acid levels in HFA mice. 16S rRNA V3 region Polymerase Chain Reaction\u2010Denaturing Gradient Gel Electrophoresis (PCR\u2010DGGE) profiles showed that HFD mice had significantly reduced microbial diversity. This reduction could be alleviated by TP, with a significant increase in the richness and diversity of colonic microbiota in the high\u2010fat diet with 0.2% TP (TPM) and high\u2010fat diet with 0.05% TP (TPL) groups (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). 454 pyrosequencing analysis showed that the HFD group had a significant increase in the Bacteroidetes to Firmicutes (F\/B) ratio (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), which could effectively be reversed by TP. The results showed that the changes in composition and diversity of colonic microbiota by TP administration suppressed the host body weight and blood lipid increase in high\u2010fat diet HFA mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>A high fat diet significantly impacted gut microbiota composition and lipid metabolism in human flora\u2010associated mice, which were largely ameliorated by tea polyphenol (TP). Therefore, TPs may be effectively used in controlling or treating obesity, hyperlipidemia and other related metabolic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14058","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:03:38Z","timestamp":1518246218000},"page":"864-873","source":"Crossref","is-referenced-by-count":129,"title":["Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High\u2010Fat Diet Treated HFA Mice"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2466-2984","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"},{"name":"Dept. of Biological and Agricultural Engineering Inst. Univ. of California Davis  Calif. U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Basic Medical Sciences Third Military Medical Univ.  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Liao","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Gu","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Basic Medical Sciences Third Military Medical Univ.  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Dept. of Laboratory Animal Science, Coll. of Food Science South China Agricultural Univ.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400071"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407076101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104816"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.04.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201501042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1403"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.05.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.236"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8100640"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128034.70732.C2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219451110"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1637"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12489-0"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"69","article-title":"Human flora\u2010associated (HFA) animals as a model for studying the role of intestinal flora in human health and disease","volume":"6","author":"Hirayama K.","year":"2005","journal-title":"Current Issues in Intestinal Microbiology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/08910609509140098"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.12938\/bifidus1982.13.1_1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.44.219"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.03.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058396"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00434.2013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2013.01.034"},{"issue":"11","key":"e_1_2_9_23_1","first-page":"1720","article-title":"Green tea catechins decrease total and low\u2010density lipoprotein cholesterol: A systematic review and meta\u2010analysis","volume":"111","author":"Kim A.","year":"2011","journal-title":"Journal of the Academy of Nutrition and Dietetics"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802926"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007508"},{"issue":"3","key":"e_1_2_9_26_1","first-page":"1","article-title":"Composition, diversity and abundance of gut microbiome in prediabetes and type 2 diabetes","volume":"2","author":"Lambeth S. M.","year":"2015","journal-title":"Journal of Diabetes and Obesity"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.11.001"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12506"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400470"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504978102"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/4441022a"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf404160e"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.05.017"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.50965"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.06.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00119.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1698S"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.59.3.695-700.1993"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.505"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020944"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2005.03.001"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00698.2006"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11450"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.3265"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.005"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05414"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300018"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000098107"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058263"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1662-7"},{"issue":"30","key":"e_1_2_9_53_1","first-page":"24","article-title":"Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans","volume":"22","author":"Walkowiak J.","year":"2013","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204672200"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-669"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf401779z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01438G"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328364f23e"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9833-9"},{"issue":"6","key":"e_1_2_9_60_1","first-page":"700","article-title":"16S rRNA\u2010base analysis of bacteroidetes and firmicutes diversity in the microbial flora of the red\u2010eared slider (Trachemys scripta elegans) intestinal tract","volume":"32","author":"Zhang W.","year":"2013","journal-title":"Genomics and Applied Biology"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-014-0592-x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0093-z"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.14058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:28:13Z","timestamp":1762176493000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.14058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,10]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/1750-3841.14058"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.14058","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,10]]}}}