{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:18:45Z","timestamp":1792685925175,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371763"],"award-info":[{"award-number":["31371763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      High chromium yeast has attracted many researchers for its high efficiency and high safety among chromium supplements. The preventive effect of oral high\u2010chromium yeast on diabetes was assessed using KK\u2010A\n                      <jats:sup>Y<\/jats:sup>\n                      mice. Sixteen\u2010wk\u2010old type 2 diabetic KK\u2010A\n                      <jats:sup>Y<\/jats:sup>\n                      mice were divided into five groups and orally administered with two types of drying processed high\u2010chromium yeast, chromium picolinate at 1000\u00a0\u03bcg Cr\/kg\/d, metformin (positive control), and normal yeast (negative control) for 13\u00a0weeks. The spray\u2010dried high\u2010chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK\u2010A\n                      <jats:sup>Y<\/jats:sup>\n                      mice (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and significantly improved fasting blood glucose, TG(triglyceride), and TCHO(total cholesterol) . Histopathological analysis showed that the spray\u2010dried high\u2010chromium yeast led to high affinities for the stains to the \u03b2\u2010cells in the islets of Langerhans and alleviated hepatic steatosis. High\u2010chromium yeast could be a potential candidate for nutritional supplement to ameliorate diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      Chromium plays an important role in fat and carbohydrate metabolism. The result show that spray\u2010dried high chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK\u2010A\n                      <jats:sup>Y<\/jats:sup>\n                      mice. As one of chromium supplements, the purpose of this study is to examine the efficacy of high chromium yeast on the type 2 diabetes and drying method on its bioactivity, which will be useful for research and development of high\u2010chromium yeast and improvement of pharmacological activity\u2010based quality control.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14138","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T14:05:53Z","timestamp":1530626753000},"page":"1956-1963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antidiabetic Effect of High\u2010Chromium Yeast Against Type 2 Diabetic KK\u2010Ay Mice"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-6207","authenticated-orcid":false,"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"Inst. of Food Science and Technology, Chinese Academy of Agricultural Science\/Key Laboratory of Agro\u2010Food Processing and Quality Control Ministry of Agriculture  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Inst. of Food Science and Technology, Chinese Academy of Agricultural Science\/Key Laboratory of Agro\u2010Food Processing and Quality Control Ministry of Agriculture  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Inst. of Food Science and Technology, Chinese Academy of Agricultural Science\/Key Laboratory of Agro\u2010Food Processing and Quality Control Ministry of Agriculture  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010yang","family":"Pang","sequence":"additional","affiliation":[{"name":"Inst. of Food Science and Technology, Chinese Academy of Agricultural Science\/Key Laboratory of Agro\u2010Food Processing and Quality Control Ministry of Agriculture  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010ping","family":"Lv","sequence":"additional","affiliation":[{"name":"Inst. of Food Science and Technology, Chinese Academy of Agricultural Science\/Key Laboratory of Agro\u2010Food Processing and Quality Control Ministry of Agriculture  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(89)90196-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1997.10718685"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(00)00241-2"},{"issue":"4","key":"e_1_2_6_5_1","first-page":"217","article-title":"Neonatal streptozotocin\u2010induced rat model of type 2 diabetes mellitus: A glance","volume":"36","author":"Arulmozhi D.","year":"2004","journal-title":"Indian Journal of Pharmacology"},{"issue":"9","key":"e_1_2_6_6_1","first-page":"831","article-title":"The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes","volume":"21","author":"Bahijiri S. 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