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Oral consumption of oregano essential oil (OEO) can reduce intestinal parasitic infections, however, its addition to therapeutic and supplementary foods is hampered by its undesirable flavor. The objective of this study was to develop a functional lipid\u2010based nutrient supplement (LNS) containing OEO, which is stable, acceptable and provides targeted intestinal delivery of bioactive. \u03b2\u2010cyclodextrin (\u03b2\u2010CyD) inclusion complexes of OEO (\u03b2\u2010CyD\u2010OEO), and carvacrol (\u03b2\u2010CyD\u2010CV) (1:1 molar) were prepared using slurry complexation (\u201020 \u00b0C) method and characterized based on encapsulation efficiency, moisture content, morphology, and 2\u2010phase\n                      <jats:italic>in vitro<\/jats:italic>\n                      digestion stability. Carvacrol (CV) content was measured using reverse phase HPLC\u2010UV. LNS containing \u03b2\u2010CyD\u2010OEO (27.2 mg encapsulate\/20 g LNS) was formulated using Indian staples and ingredients. Discriminatory sensory tests (triangle) were performed with college students (n\u00a0=\u00a058) and low\u2010income women (n\u00a0=\u00a025), with young children at home (1 to 6 years), living in Mehsana, India to evaluate differences between LNS with and without bioactive ingredient (\u03b2\u2010CyD\u2010OEO only). Moisture of dried complexes ranged 9.1% to 9.7% d.b., whereas water activity 0.35 to 0.412. The complex size and encapsulation efficiency of \u03b2\u2010CyD\u2010OEO and \u03b2\u2010CyD\u2010CV were 1.5 to 7 \u03bcm and 4 to 20 \u03bcm, and 86.04\u00a0\u00b1\u00a04.48% and 81.39\u00a0\u00b1\u00a03.34%, respectively. The bioactive complexes were stable through the gastric and intestinal phases. Bioaccessibility of encapsulated CV ranged 6.0% to 7.7%. Sensory tests revealed no differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a00.05) in color, aroma, and taste between LNS with and without \u03b2\u2010CyD\u2010OEO complexes. Functionalization of LNS with \u03b2\u2010CyD\u2010OEO is feasible based on\n                      <jats:italic>in vitro<\/jats:italic>\n                      stability and sensory studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      Despite its antiparasitic activities, the addition of oregano essential oil into foods is limited due to its strong flavor and volatility. In this study, we evaluated the encapsulation of oregano essential oil with \u03b2\u2010cyclodextrin and its addition into lipid\u2010based nutrition supplements. The results revealed that complex encapsulation efficiency was above 80%. Also, the bioactive complexes were stable under\n                      <jats:italic>in vitro<\/jats:italic>\n                      gastrointestinal conditions. Sensory evaluation of LNS with and without encapsulated essential oil showed no difference in terms of color, aroma, and taste. The functional LNS can both address nutrient insufficiency as well as parasitic infection among malnourished populations in low\u2010resource settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14178","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T10:21:11Z","timestamp":1526552471000},"page":"1748-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functionalization of Lipid\u2010Based Nutrient Supplement with \u03b2\u2010Cyclodextrin Inclusions of Oregano Essential Oil"],"prefix":"10.1111","volume":"83","author":[{"given":"Shashank","family":"Gaur","sequence":"first","affiliation":[{"name":"Dept. of Food Science and Human Nutrition Univ. of Illinois at Urbana\u2010Champaign  Urbana IL 61801 U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emely C.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Dept. of Food Science and Human Nutrition Univ. of Illinois at Urbana\u2010Champaign  Urbana IL 61801 U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Ojha","sequence":"additional","affiliation":[{"name":"Dept. of Food Science and Technology Natl. 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