{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:52:04Z","timestamp":1793379124968,"version":"4.5.0"},"reference-count":110,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4\u2010dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL\u20102 and COX\u20102 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies.<\/jats:p>","DOI":"10.1111\/1750-3841.14198","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T16:13:01Z","timestamp":1529597581000},"page":"1781-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates"],"prefix":"10.1111","volume":"83","author":[{"given":"Muhammad","family":"Imran","sequence":"first","affiliation":[{"name":"Univ. Inst. of Diet and Nutritional Sciences, Faculty of Allied Health Sciences The Univ. of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Dept. of Environmental Sciences COMSATS University Islamabad, Vehari Campus  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Amir","family":"Gilani","sequence":"additional","affiliation":[{"name":"Univ. Inst. of Diet and Nutritional Sciences, Faculty of Allied Health Sciences The Univ. of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaista","family":"Khan","sequence":"additional","affiliation":[{"name":"Dept. of Biochemistry Shah Abdul University  Khairpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-0971","authenticated-orcid":false,"given":"Muhammad Wasim","family":"Sajid","sequence":"additional","affiliation":[{"name":"Dept. of Biosciences COMSATS University Islamabad, Sahiwal Campus  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rai Muhammad","family":"Amir","sequence":"additional","affiliation":[{"name":"Inst. of Food and Nutritional Sciences PMAS\u2010Arid Agriculture Univ.  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"12","article-title":"Natural antioxidant composition as correlated to stability of some Tunisian virgin olive oils","volume":"132","author":"Abaza L.","year":"2005","journal-title":"Rivista Italiano Delle Sostanze Gresse"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60716"},{"key":"e_1_2_4_4_1","first-page":"31","article-title":"Antiproliferative effect of oleuropein in prostate cell lines","volume":"41","author":"Acquaviva R.","year":"2012","journal-title":"International Journal of Oncology"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.07.029"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf070628u"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00071a014"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91647-U"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf980451r"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.198319830417"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151018508"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.2.191"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(99)00221-6"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00853-X"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.11.2085"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.02.025"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-12-0241"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf400796p"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.806674"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.741758"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300323"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-2-1"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.922204"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8015877"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.049"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500373000"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf011264n"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.112912"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.10.013"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.12.2996"},{"issue":"7","key":"e_1_2_4_31_1","article-title":"Synergistic anti\u2010breast\u2010cancer effects of combined treatment with oleuropein and doxorubicin in vivo","volume":"23","author":"Elamin M. H.","year":"2017","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf001258b"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.614"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.1.42"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.8.1411"},{"key":"e_1_2_4_36_1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"15","author":"Ferlay J.","year":"2010","journal-title":"International Journal of Cancer"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3604-0"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl328"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.06.021"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826070500474113"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300465"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21083"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500605"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200800204"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-006-0633-8"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.04.001"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.06.161"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-009-9191-2"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23148"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.11.6739"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12365625"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00994-3"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.104992"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.08.026"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.11.022"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.071"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01292-0"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2853"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0627"},{"key":"e_1_2_4_60_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3989\/gya.2004.v55.i1.145","article-title":"Olive oil and cancer","volume":"55","author":"L\u00f3pez S.","year":"2004","journal-title":"Grasas Aceites"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680096113139990035"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01350-8"},{"key":"e_1_2_4_63_1","first-page":"1217","article-title":"Anti\u2010proliferation and migration effects of oleuropein on human A549 lung carcinoma cells","volume":"32","author":"Mao W.","year":"2012","journal-title":"Latin American Journal of Pharmacy"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-80"},{"issue":"4","key":"e_1_2_4_65_1","first-page":"433","article-title":"Analyzing effects of extra\u2010virgin olive oil polyphenols on breast cancer\u2010associated fatty acid synthase protein expression using reverse\u2010phase protein microarrays","volume":"22","author":"Menendez J. A.","year":"2008","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2001.5160"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.2.341"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.6.945"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1999.02653.x"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-010-0177-7"},{"issue":"3","key":"e_1_2_4_71_1","first-page":"135","article-title":"Olive: Native of Mediterranean region and health benefits","volume":"2","author":"Omar S. H.","year":"2008","journal-title":"Pharmacognosy Reviews"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2010.05.005"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1997.11720725"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00015-2"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.05.002"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/12051153"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(02)00268-6"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6119"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf051647b"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4238(01)00287-4"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9645-0"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.0026"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900111"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.4.703"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16757"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC4601_08"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.54.10.756"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00187G"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jmicro.a023443"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00855-3"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0156"},{"key":"e_1_2_4_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500498"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.47.363"},{"key":"e_1_2_4_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2003.tb00222.x"},{"key":"e_1_2_4_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.08.014"},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00229-2"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000468l"},{"issue":"12","key":"e_1_2_4_98_1","first-page":"5371","article-title":"Antiproliferative, antioxidant and anti\u2010inflammatory effects of hydroxytyrosol on human hepatoma HepG2 and Hep3B cell lines","volume":"32","author":"Tutino V.","year":"2012","journal-title":"Anticancer Research"},{"key":"e_1_2_4_99_1","first-page":"237","article-title":"Preparation of hydroxytyrosol","volume":"15","author":"Verhe R.","year":"1992","journal-title":"Bull. Liason\u2010Groupe Polyphenols"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8735"},{"key":"e_1_2_4_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01216-3"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.18.2169"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.1028"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.3.409"},{"key":"e_1_2_4_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601917"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu3100839"},{"key":"e_1_2_4_107_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3266"},{"key":"e_1_2_4_108_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.14012FP"},{"key":"e_1_2_4_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.01.028"},{"key":"e_1_2_4_110_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515000884"},{"key":"e_1_2_4_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1339818"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.14198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:46:38Z","timestamp":1762199198000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.14198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":110,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/1750-3841.14198"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.14198","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"assertion":[{"value":"2017-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}