{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:26:24Z","timestamp":1791606384728,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["15ZR1428900"],"award-info":[{"award-number":["15ZR1428900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371809"],"award-info":[{"award-number":["31371809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771956"],"award-info":[{"award-number":["31771956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lactic acid bacteria (LAB) have been used as ingredients of functional foods to promote health and prevent diseases because of their beneficial effects. This study aimed to investigate the antioxidative effects of LAB on the hepatotoxicity in D\u2010galactose\u2010induced aging mice. LAB were isolated from the traditional Chinese fermented foods and screened by the tolerance of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). Male ICR (Institute of Cancer Research) mice were subcutaneously injected with D\u2010galactose for 5 weeks and then gastric gavage with LAB for 6 weeks. The results showed that\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    AR113 and AR501, and\n                    <jats:italic>Pediococcu pentosaceus<\/jats:italic>\n                    AR243 could tolerate up to 1.5 mM H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    , and they could live through simulated gastrointestinal tract (GIT) to colonizing the GIT of host.\n                    <jats:italic>In\u00a0vivo<\/jats:italic>\n                    , oral administration of\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    AR113 and AR501 improved the antioxidant status of D\u2010galactose\u2010induced oxidative stress mice such as alleviated liver damages and reduced abnormal activities of superoxide dismutase, glutathione peroxidase, and catalase to normal levels. In addition,\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    AR501 markedly elevated the gene expression of nuclear factor erythroid\u20102\u2010related factor 2 and upregulated the expressions of several antioxidant genes such as glutathione reductase, glutathione S\u2010transferase, glutamate\u2010cysteine ligase catalytic subunit, glutamate\u2010cysteine ligase modifier subunit, and NAD(P)H quinone oxidoreductase 1 in the liver of an aging mice. Therefore,\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    AR501 could be a good candidate for producing antiaging functional foods.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.14200","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T13:58:26Z","timestamp":1529071106000},"page":"1990-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["<i>Lactobacillus plantarum<\/i>\n                    AR501 Alleviates the Oxidative Stress of D\u2010Galactose\u2010Induced Aging Mice Liver by Upregulation of Nrf2\u2010Mediated Antioxidant Enzyme Expression"],"prefix":"10.1111","volume":"83","author":[{"given":"Xiangna","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medical Instrument and Food Engineering, Shanghai Engineering Research Center of Food Microbiology Univ. of Shanghai for Science and Technology  No. 516 Jungong 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