{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:37:11Z","timestamp":1791110231256,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105\u20102320\u2010B\u2010039\u2010039"],"award-info":[{"award-number":["105\u20102320\u2010B\u2010039\u2010039"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti\u2010inflammatory effect. The administration of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      strains reducing the risk of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection is well accepted. In this study, the therapeutic effects against\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection of baicalin, baicalein, and\n                      <jats:italic>L. rhamnosus<\/jats:italic>\n                      JB3 (LR\u2010JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti\u2010\n                      <jats:italic>H. pylori<\/jats:italic>\n                      activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the\n                      <jats:italic>vacA<\/jats:italic>\n                      gene expression of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      and interfered with the adhesion and invasion ability of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      to AGS cells, as well as decreased\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010induced interleukin (IL)\u20108 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited\n                      <jats:italic>H. pylori<\/jats:italic>\n                      growth in the mice stomachs. Serum IL\u20101\u03b2 levels and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR\u2010JB3 on eradicating\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infections was observed. Thus, administrating baicalin, baicalein, or LR\u2010JB3 for an\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR\u2010JB3 on attenuating the virulence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      . The synergistic effect with baicalein and LR\u2010JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      Baicalin and baicalein exert health promotion and avoidance of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infections by interfering with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      growth and virulence.\n                      <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                      JB3 was used to reduce the gastric inflammation caused by\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14372","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T06:13:24Z","timestamp":1542953604000},"page":"3118-3125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Baicalin, Baicalein, and\n                    <i>Lactobacillus Rhamnosus<\/i>\n                    JB3 Alleviated\n                    <i>Helicobacter pylori<\/i>\n                    Infections\n                    <i>in Vitro<\/i>\n                    and\n                    <i>in Vivo<\/i>"],"prefix":"10.1111","volume":"83","author":[{"given":"Mu\u2010En","family":"Chen","sequence":"first","affiliation":[{"name":"Dept. of Biological Science and Technology China Medical Univ.  Taichung 40402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu\u2010Hsian","family":"Su","sequence":"additional","affiliation":[{"name":"Dept. of Biological Science and Technology China Medical Univ.  Taichung 40402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai\u2010Sing","family":"Yang","sequence":"additional","affiliation":[{"name":"Dept. of Medical Research, China Medical Univ. Hospital China Medical Univ.  Taichung 40447 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Dept. of Sport Performance Natl. Taiwan Univ. of Sport  Taichung 40404 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chi","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical Univ.  Taichung 40402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical Univ.  Taichung 40402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-7475","authenticated-orcid":false,"given":"Yuan\u2010Man","family":"Hsu","sequence":"additional","affiliation":[{"name":"Dept. of Biological Science and Technology China Medical Univ.  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