{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:42:48Z","timestamp":1788295368288,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2016J06009"],"award-info":[{"award-number":["2016J06009"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81741163"],"award-info":[{"award-number":["81741163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the antidiabetic activity of water\u2013ethanol extract of green macroalgae\n                    <jats:italic>Enteromorpha prolifera<\/jats:italic>\n                    (EPW) and its flavonoid\u2010rich fraction less than 3 kDa (EPW3) in type 2 diabetic mice induced by streptozotocin and a high\u2010sucrose\/high\u2010fat diet. The major active compounds were identified using ultra\u2010performance liquid chromatography coupled with quadrupole\u2010time\u2010of\u2010flight\u2010tandem mass spectrometry. Quantitative gene expression analysis of the insulin signaling pathway was performed. The effects of EPW3 on gut microflora in diabetic mice were analyzed by high\u2010throughput 16S rRNA gene sequencing. The results showed EPW3 treatment decreased the fasting blood glucose, improved oral glucose tolerance, and protected against liver and kidney injury with reduced inflammation in diabetic mice. The active principle of EPW3 revealed hypoglycemic\u00a0effect as indicated by activation of the IRS1\/PI3K\/AKT and inhibition of the JNK1\/2 insulin pathway in liver. Furthermore, the treatment significantly enriched the abundance of\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    and\n                    <jats:italic>Alisties<\/jats:italic>\n                    , which were positive correlation of metabolic phenotypes. These findings indicated that EPW3 possessed great therapeutic potential as adjuvant therapy for type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.14415","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T20:15:27Z","timestamp":1545250527000},"page":"165-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Antidiabetic Potential of Green Seaweed\n                    <i>Enteromorpha prolifera<\/i>\n                    Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice"],"prefix":"10.1111","volume":"84","author":[{"given":"Xin","family":"Yan","sequence":"first","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry Univ.  Fuzhou 350002 Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural Univ.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopeng","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry Univ.  Fuzhou 350002 Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry Univ.  Fuzhou 350002 Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Miao","sequence":"additional","affiliation":[{"name":"Food Chemistry and Technology Dept. Teagasc Food Research Centre  Moorepark, Fermoy Co. Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry Univ.  Fuzhou 350002 Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-632X","authenticated-orcid":false,"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry Univ.  Fuzhou 350002 Fujian China"},{"name":"Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae Quanzhou Normal Univ.  Quanzhou 362000 Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2017.14.364"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407076101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025792"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3282efdebb"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0804"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03006-05"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02842.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01137"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9020196"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.12.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.46.Suppl_S25"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.08.032"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-148072"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504978102"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/4441022a"},{"key":"e_1_2_9_20_1","first-page":"675201","article-title":"Polysaccharides from Enteromorpha prolifera improve glucose metabolism in diabetic rats","author":"Lin W.","year":"2015","journal-title":"Journal of Diabetes Research"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.041"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0339-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60614-4"},{"issue":"4","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1681\/ASN.V641186","article-title":"Pathogenesis of cyclosporine nephropathy: Roles of angiotensin II and osteopontin","volume":"6","author":"Pichler R. 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