{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:59:43Z","timestamp":1780545583954,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, CONACyT Mexico"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      High blood pressure can lead to cardiovascular diseases. The objective of this work was to obtain protein hydrolysates with antihypertensive potential from chia oil industry meal byproduct. Chia seed protein isolates (CPIs) were obtained from chia seed meal byproduct. CPI was hydrolyzed using different proteases (alcalase, pepsin, trypsin, and \u03b1\u2010chymotrypsin) and their biological potential was evaluated using\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in silico<\/jats:italic>\n                      approaches. Chia seed pepsin protein hydrolysate showed the highest angiotensin\u2010converting enzyme inhibition potential IC\n                      <jats:sub>50<\/jats:sub>\n                      of 0.128\u00a0mg\/mL (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) compared to the rest of hydrolysates. Peptide sequence LIVSPLAGRL presented the lowest predicted binding energy and highest inhibition potential (\u20139.5\u00a0kcal\/mol) compared to other sequenced peptides and positive controls (captopril and lisinopril). Chia peptides showed potential to block angiotensin\u2010converting enzyme by interacting with its catalytic site. Chia seed oil industry meal byproduct could be used as an inexpensive source of protein and bioactive peptides with antihypertensive potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>This research shows an upcycling alternative for chia oil industry byproduct. Chia meal is a rich source of protein and can be used to generate bioactive peptides with antihypertensive potential. Chia protein isolate was obtained from chia meal and hydrolyzed using different enzymes, pepsin showed the highest antihypertensive potential. Chia meal waste could be a low\u2010cost source of protein and protein hydrolysates that could be used as a food ingredient with antihypertensive potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14503","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T08:28:32Z","timestamp":1555576112000},"page":"1170-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Chia Seed (\n                    <i>Salvia hispanica L<\/i>\n                    .) Pepsin Hydrolysates Inhibit Angiotensin\u2010Converting Enzyme by Interacting with its Catalytic Site"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-9853","authenticated-orcid":false,"given":"Brenda","family":"San Pablo\u2010Osorio","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco (CIATEJ) A.C., Unidad de Tecnolog\u00eda Alimentaria  Camino Arenero 1227 El Baj\u00edo, Zapopan, Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-8711","authenticated-orcid":false,"given":"Luis","family":"Mojica","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco (CIATEJ) A.C., Unidad de Tecnolog\u00eda Alimentaria  Camino Arenero 1227 El Baj\u00edo, Zapopan, Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-4979","authenticated-orcid":false,"given":"Judith Esmeralda","family":"Ur\u00edas\u2010Silvas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco (CIATEJ) A.C., Unidad de Tecnolog\u00eda Alimentaria  Camino Arenero 1227 El Baj\u00edo, Zapopan, Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2012.08.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf970294g"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2016.06.032"},{"key":"e_1_2_8_5_1","first-page":"248","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2010dye binding","volume":"72","author":"Bradford M. M.","year":"1976","journal-title":"AnBio"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2011.07.012"},{"key":"e_1_2_8_7_1","first-page":"151","article-title":"Propiedades funcionales de la harina y de los aislados prot\u00e9icos de la semilla de guan\u00e1bana (Annona muricata)","volume":"17","author":"Chaparro S. P.","year":"2014","journal-title":"Revista U.D.CA Actualidad & Divulgaci\u00f3n Cient\u00edfica"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.11.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.180"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1990.tb00717.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.05.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1457"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.06.051"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v59.29788"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-011-1841-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.04.064"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90053-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2010.11.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1977.tb14476.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.03.127"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-018-9688-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2014.02.035"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.08.020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520120124"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2006.tb15612.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b06078"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf201911p"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO00093B"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700362"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(03)00174-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4001555"},{"key":"e_1_2_8_33_1","first-page":"385","article-title":"Inhibici\u00f3n de la enzima convertidora de angiotensina I con hidrolizados proteicos de Jatropha curcas","volume":"46","author":"Marrufo Estrada D. M.","year":"2012","journal-title":"Acta Bioquimica Clinica Latinoamericana"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2015.11.036"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.8053"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm333"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_8_38_1","first-page":"455","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Olson A. J.","year":"2009","journal-title":"Journal of Computational Chemistry"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2015.05.033"},{"key":"e_1_2_8_40_1","unstructured":"Osborne T. B.(1924).The vegetable proteins. Green NY: Longmans."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-457x.6349"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.07.019"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020522t"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf3034978"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/158482"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf001453q"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2015.07.033"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.02.062"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja204042f"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2015.06.002"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/19476330903223580"},{"key":"e_1_2_8_53_1","first-page":"79","article-title":"Establecimiento de condiciones \u00f3ptimas para obtener un aislado proteico de avellana chilena (Gevuina avellana, Mol)","volume":"62","author":"Villarroel M.","year":"2012","journal-title":"Archivos Latinoamericanos de Nutricion"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-012-0919-1"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-011-0122-6"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.07.026"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.14503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.14503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:52:20Z","timestamp":1762167140000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.14503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,18]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/1750-3841.14503"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.14503","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,18]]},"assertion":[{"value":"2018-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}