{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:39:56Z","timestamp":1790185196393,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["250930"],"award-info":[{"award-number":["250930"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>We evaluated the effect of krill oil (KO) supplement on seizures induced by pentylenetetrazole (PTZ) in animals with previous febrile seizures (FSs) induced by hyperthermia to determine its effectiveness in seizure susceptibility and as an anticonvulsant. Male Wistar rats with FS separated into water (W, 1 mL), palm oil (PO, 300\u00a0mg\/kg, total volume 1 mL), or KO (300\u00a0mg\/kg, total volume 1 mL) groups. All drugs were administered chronically via the intragastric route. Electrical activity was recorded by intracranial EEG simultaneously with convulsive behavior. All animals\u2019 brains were processed by immunofluorescence against GFAP, NeuN, and connexins (Cx); cellular quantification was performed in hippocampus and pyramidal or granular layer thickness was evaluated with cresyl violet (CV) staining. The results showed a significant delay in convulsive behavior and a slight increased survival time after PTZ administration in the group treated with KO compared with PO and W groups. The epileptiform activity showed high amplitude and frequency, with no significant differences between groups, nor were there differences in the number and duration of discharge trains. KO and PO increased the number of astrocytes and the number of neurons compared with the W group. KO and PO decreased the expression of Cx36 without affecting Cx43 expression or the thickness of layers. Based on these data, we consider it important to perform more experiments to determine the anticonvulsant role of KO, taking into account the partial effect found in this study. KO could be used as a coadjuvant of traditional anticonvulsive treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>In this study was evaluated the anticonvulsive effect of a chronic krill oil (KO) supplement in animals with seizures. Results showed that KO had partial anticonvulsive effects measured by EEG activity and convulsive behavior analysis. These data justify further research that looks at KO supplementation as a prospective coadjuvant of pharmacologic management of seizure disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14679","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T02:45:02Z","timestamp":1560998702000},"page":"1703-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Chronic Krill Oil Supplement on Seizures Induced by Pentylenetetrazole in the Hippocampus of Adult Rats with Previous Febrile Seizures"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0345-2216","authenticated-orcid":false,"given":"Laura","family":"Medina\u2010Ceja","sequence":"first","affiliation":[{"name":"Laboratory of Neurophysiology, Dept. of Cellular and Molecular Biology, CUCBA Univ. of Guadalajara  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridha","family":"Villalpando\u2010Vargas","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, Dept. of Cellular and Molecular Biology, CUCBA Univ. of Guadalajara  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria I.","family":"Gir\u00f3n de la Cruz","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, Dept. of Cellular and Molecular Biology, CUCBA Univ. of Guadalajara  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M.","family":"Lara\u2010 Vazquez","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, Dept. of Cellular and Molecular Biology, CUCBA Univ. of Guadalajara  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Flores\u2010Mancilla","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology and Behavior, Human Medicine and Health Science Academic Unit Autonomous Univ. of Zacatecas  Zacatecas M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Salazar\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, Dept. of Cellular and Molecular Biology, CUCBA Univ. of Guadalajara  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Morales\u2010Villagr\u00e1n","sequence":"additional","affiliation":[{"name":"MexBio Research Innovations S.A. de C.V.  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