{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:15:04Z","timestamp":1762186504905,"version":"build-2065373602"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012M3A9C4048761"],"award-info":[{"award-number":["2012M3A9C4048761"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extracts of several plants possess antithrombotic effects. Herein, we examined the antithrombotic effects of different extracts of\n                    <jats:italic>Artemisia princeps<\/jats:italic>\n                    Pampanini prepared using distilled water, hot distilled water, 70% ethanol, or subcritical water. The antithrombotic effects were determined using a co\u2010culture system consisting of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1)\u2010treated EA.hy926 cells and THP\u20101 cells. In addition, the coagulation time of plasma collected from healthy volunteers was evaluated in terms of the prothrombin time and activated partial thromboplastin time. A carotid arterial thrombosis model was induced by ferric chloride in Sprague Dawley rats. The rats were treated with either sterile water or three different doses of the subcritical water extract for 2 weeks. The thrombus weight, gene expression of cell adhesion molecules, and histological characteristics were assessed. The results of\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies revealed a significant inhibition in the adhesion of monocytes to EA.hy926 cells stimulated by TNF\u2010\u03b1 in the subcritical water extract\u2010treated group. We also observed considerable suppression of the occlusion and mRNA expression of cell adhesion molecules in the\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments. This study suggests that\n                    <jats:italic>Artemisia princeps<\/jats:italic>\n                    Pampanini may have the potential to improve blood coagulation.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.14786","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:44:34Z","timestamp":1568202274000},"page":"3037-3044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antithrombotic Effect of\n                    <i>Artemisia princeps<\/i>\n                    Pampanini Extracts\n                    <i>in Vitro<\/i>\n                    and in FeCl\n                    <sub>3<\/sub>\n                    \u2010Induced Thrombosis Rats"],"prefix":"10.1111","volume":"84","author":[{"given":"Kyeong Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Dept. of Food Science and Technology Seoul Natl. Univ. of Science and Technology  232, Gongneung\u2010ro Nowon\u2010gu, Seoul 01811 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Seo","family":"Kim","sequence":"additional","affiliation":[{"name":"Dept. of Food Science and Technology Seoul Natl. Univ. of Science and Technology  232, Gongneung\u2010ro Nowon\u2010gu, Seoul 01811 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu Reum","family":"Seok","sequence":"additional","affiliation":[{"name":"Dept. of Biomedical Laboratory Science Eulji Univ.  Seongnam\u2010si Gyeonggi\u2010do 13135 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Dept. of Biomedical Laboratory Science Eulji Univ.  Seongnam\u2010si Gyeonggi\u2010do 13135 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-2726","authenticated-orcid":false,"given":"Ji Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Dept. of Food Science and Technology Seoul Natl. Univ. of Science and Technology  232, Gongneung\u2010ro Nowon\u2010gu, Seoul 01811 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2011.06.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2011.12.019"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"245","article-title":"Hepatoprotective effect of fermented Artemisia princeps Pampanini by lactic acid bacteria","volume":"38","author":"Choi H. 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