{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:40Z","timestamp":1793317480136,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372404"],"award-info":[{"award-number":["81372404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Alkylresorcinols are phenolic lipids that mainly exist in the cortex of grains, and they exhibit anticancer activity against various cancer cells\n                      <jats:italic>in vitro<\/jats:italic>\n                      . However, the underlying action mechanisms are still unclear. In our study, the influence of alkylresorcinols C\n                      <jats:sub>19:0<\/jats:sub>\n                      and C\n                      <jats:sub>21:0<\/jats:sub>\n                      (ARs) upon migration, invasion, and autophagy in human hepatoblastoma HepG2 cells was evaluated. Results showed that ARs at 80 and 160 \u00b5g\/mL significantly suppressed cells proliferation, migration, and invasion, downregulated the expression of proteins RhoA and MMP\u20107 associated with migration and invasion. ARs at 160 \u00b5g\/mL, the rate of LC3 puncta was appreciably increased. After autophagy was blocked by 3\u2010MA or CQ, the expression of LC3II was significantly increased in 3\u2010MA+ARs group and p62 was significantly decreased in CQ+ARs group. The results indicate that ARs may promote autophagic flow. ARs (80, 160 \u00b5g\/mL) significantly inhibited the expression of proteins p\u2010mTOR, p\u2010PI3K, and p\u2010Akt related to the PI3K\/Akt pathway. The results of the present study suggest that ARs can activate autophagy and suppresses the biological behaviors of HepG2 cells by inhibiting the activation of MMP\u20107, Rho\/Rho\u2010associated protein kinase, and activation of the phosphatidylinositol 3\u2010kinase\/Akt signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>The anticancer mechanism of ARs in wheat bran was studied, which provided a basis for the development of anticancer functional auxiliary food with wheat bran as raw material. It is of great practical significance to promote the effective utilization of grain processing by\u2010products and improve the economic benefits of the grain industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.14789","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T11:35:22Z","timestamp":1568633722000},"page":"3063-3068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Alkylresorcinols on Autophagy, Migration, and Invasion of HepG2 Cells"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-6119","authenticated-orcid":false,"given":"Ya\u2010Zhou","family":"Guo","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Jiangsu Univ.  Zhenjiang 212013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-4509","authenticated-orcid":false,"given":"Xiao\u2010Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Jiangsu Univ.  Zhenjiang 212013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangsu Univ.  Zhenjiang 212013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"290","article-title":"Clinicopathologic and prognostic significance of matrilysin expression at the invasive front in human colorectal cancers","volume":"95","author":"Adachi Y.","year":"2015","journal-title":"International Journal of Cancer"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcs.2016.05.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.09.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401751"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14048213"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0355-0"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"649","article-title":"Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro","volume":"6","author":"Gasiorowski K.","year":"2001","journal-title":"Cellular and Molecular Biology Letters"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740450106"},{"issue":"23","key":"e_1_2_8_10_1","first-page":"161","article-title":"Apoptosis\u2010inducing effect and underlying mechanism of aroma components from douchi on human nasopharyngeal carcinoma CNE\u20101 cells","volume":"39","author":"Guijie L.","year":"2018","journal-title":"Food Science"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.01.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.518134"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.02.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.04.030"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5664"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"1021","article-title":"Effects of ginkgol C17:1 on cisplatin\u2010induced autophagy and apoptosis in HepG2 cells","volume":"15","author":"Liu J.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.07.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.10.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711796011292"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbm.2018.62002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.04.020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0340456"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00021a014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1916"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi991509d"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207387"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0121"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60365a049"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01025a046"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.07.009"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29308-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.072"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.05.025"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.14789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.14789","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.14789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:43:56Z","timestamp":1762184636000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.14789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/1750-3841.14789"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.14789","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]},"assertion":[{"value":"2019-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}