{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:08:40Z","timestamp":1789182520738,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This work aimed includes performing the sclerotia chemical profile and evaluates their biological effects on mutagenesis, oxidative stress, cancer, and malaria. A chemical profile was determined by ultraperformance liquid chromatography mass spectrometry (UHPLC\u2013HRMS) analysis dereplicating norditerpenoid dilactone, sclerolide, and other compounds. The GI\n                    <jats:sub>50<\/jats:sub>\n                    values to cancer cells (19.8 to 277.6\u00a0\u00b5g\/mL) were higher than normal (16.05\u00a0\u00b5g\/mL), meaning high cytotoxicity. Regarding the oxidative stress, the results showed that the all AcOET fraction concentrations tested on IMR90 noncancer cell increased reactive oxygen species (ROS) production in more intense way (by fivefold) than in tested cancer cells. The\n                    <jats:italic>in vivo<\/jats:italic>\n                    study showed an increase of the following biomarkers (by 296.00%): % DNA in comet tail in peripheral blood and liver cells; micronucleated erythrocytes and colon cells and lipid serum peroxidation. These results indicate the sclerotia as genotoxic and mutagenic agent and its contamination may lead to fungal toxic effects with a risk to human health.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.14910","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T08:34:49Z","timestamp":1574325289000},"page":"3866-3875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Sclerotinia Sclerotiorum<\/i>\n                    (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects\n                    <i>In Vivo<\/i>\n                    and\n                    <i>In Vitro<\/i>"],"prefix":"10.1111","volume":"84","author":[{"given":"Carolina Girotto","family":"Pressete","sequence":"first","affiliation":[{"name":"Nutrition Faculty Federal Univ. of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Santos Vieira","family":"Giannini","sequence":"additional","affiliation":[{"name":"Nutrition Faculty Federal Univ. of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Aparecida Chagas","family":"de Paula","sequence":"additional","affiliation":[{"name":"Federal Univ. of Alfenas Chemistry Inst.  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