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There is growing evidence that the gut microbiota can affect the response to chemo\u2010 and immunotherapeutic drugs by modulating efficacy and\/or toxicity, and diet is the most important factor affecting the gut microbiota. In this study, we assessed the auxiliary antitumor effects of immunomodulatory fungal proteins from\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    (HEP) administered with the chemotherapy drug 5\u2010Fluorouracil (5\u2010Fu), and we attempted to identify new potential prebiotic bacteria for auxiliary antitumor treatment. There were 1,455 proteins identified from\n                    <jats:italic>H. erinaceus<\/jats:italic>\n                    . In a xenografted mouse model of cancer, HEP with 5\u2010Fu significantly suppressed tumor growth, inhibited inflammatory markers such as interferon (IFN)\u2010\u03b3, interleukin (IL)\u20101\u03b2, IL\u20102, IL\u20106, tumor necrosis factor (TNF)\u2010\u03b1, and lipopolysaccharide (LPS), and regulated the expression of Akt, CCDN1, CKD4, FOXM1, MMP7, MYC, PPAR\u2010\u03b1, and PPAR\u2010\u03b3. 16S rRNA sequencing showed that HEP ameliorated the dysbacteriosis induced by 5\u2010Fu, as it inhibited certain aerobic and microaerobic bacteria including\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    ,\n                    <jats:italic>Flavobacteriaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Christensenellaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Anoxybacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Aggregatibacter<\/jats:italic>\n                    ,\n                    <jats:italic>Comamonadaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Planococcaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Desulfovibrionaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Sporosarcina<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Aerococcaceae<\/jats:italic>\n                    , and\n                    <jats:italic>Bilophila<\/jats:italic>\n                    in the xenografted mice, and increase some probiotic bacteria such as\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Gemellales<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Sutterella<\/jats:italic>\n                    ,\n                    <jats:italic>Anaerostipes<\/jats:italic>\n                    ,\n                    <jats:italic>Roseburia<\/jats:italic>\n                    ,\n                    <jats:italic>Lachnobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Desulfovibrio<\/jats:italic>\n                    . This demonstrates that HEP could promote the antitumor efficacy of 5\u2010Fu by improving the microbiota composition, the immune inflammatory response, and homeostasis.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.15134","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T17:23:45Z","timestamp":1590600225000},"page":"1872-1890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Auxiliary antitumor effects of fungal proteins from\n                    <i>Hericium erinaceus<\/i>\n                    by target on the gut microbiota"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-3456","authenticated-orcid":false,"given":"Dongdong","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-1876","authenticated-orcid":false,"given":"Xiangxiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences  Guangzhou 510070 China"},{"name":"Academy of Life Sciences Jinan Univ.  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