{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:16:20Z","timestamp":1764519380027,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The funding of Synergy Research by the National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition"},{"name":"The management Expenses Grants by the National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We evaluated the influence of pine bark extract (PBE) on organs, the cytochrome\u2010P450 (CYP) activities in liver and estrogenic effects in normal and ovariectomized (OVX) female mice. The PBE did not affect organ weights and liver\u2010function indexes (activities of alkaline phosphatase, aspartate amino transferase, and alanine amino transferase) at doses; 0.04%, 0.4%, and 2.0% PBE in the diet, in normal and OVX female mice. In the OVX mice, CYP1A1 activity was significantly higher in the 0.4% and 2.0% PBE groups than in the OVX control group, and in the 0.4% and 2.0% PBE groups were significantly higher than in the 0.04% PBE group. CYP1A2 and 3A4 activities were significantly higher in the 2.0% PBE group than in all other groups. The PBE did not affect uterine weight and femoral bone mineral density at all PBE doses. These results showed that the dose of PBE at the recommended human intake, had no toxic and estrogenic effects in normal female and OVX mice, however, it may need attention to use the excess intake of PBE with some drugs in postmenopausal women.<\/jats:p>","DOI":"10.1111\/1750-3841.15160","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T11:03:30Z","timestamp":1589454210000},"page":"1956-1962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of safety and efficacy of pine bark extract in normal and ovariectomized mice"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-1145","authenticated-orcid":false,"given":"Takashi","family":"Kondo","sequence":"first","affiliation":[{"name":"National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition  1\u201023\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108636 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Ishimi","sequence":"additional","affiliation":[{"name":"National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition  1\u201023\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108636 Japan"},{"name":"NODAI Research Institute Tokyo University of Agriculture  1\u20101\u20101, Sakuragaoka Setagaya\u2010ku Tokyo 156\u20138502 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition  1\u201023\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108636 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tousen","sequence":"additional","affiliation":[{"name":"National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition  1\u201023\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108636 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1155\/2019\/5713606"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.3399\/bjgp18X699101"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"The interaction between the gut microbiota and herbal medicines","author":"An X.","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.3945\/jn.110.133025"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.3390\/ijms18112353"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1186\/gb-2014-15-7-r89"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1007\/s00394-015-0852-y"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1021\/acs.jafc.8b04093"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.3748\/wjg.v25.i46.6704"},{"issue":"7","key":"e_1_2_9_11_1","first-page":"10893","article-title":"Pycnogenol\u00ae treatment inhibits bone mineral density loss and trabecular deterioration in ovariectomized rats","volume":"8","author":"Huang G.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1359\/jbmr.2000.15.11.2251"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"1","article-title":"Pharmaceutical and nutraceutical effects of pinus pinaster bark extract","volume":"6","author":"Iravani S.","year":"2011","journal-title":"Research in Pharmaceutical Sciences"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.4236\/pp.2013.42036"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"134","article-title":"The current status of health food\u2010 or supplement\u2010related adverse health effects","volume":"14","author":"Koike M.","year":"2013","journal-title":"Japanese Journal of Drug Informatics"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.5455\/jice.20160723124347"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.1124\/jpet.114.220277"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.1089\/jmf.2005.8.14"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.2147\/IJWH.S75389"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"170","article-title":"Two cases of spondylometaphyseal dysplasia. literature review and discussion of the genetic inheritance of the disease","volume":"20","author":"Nores J. 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