{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:34:58Z","timestamp":1762191298750,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2017\u201067017\u201026519"],"award-info":[{"award-number":["2017\u201067017\u201026519"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Butyrate is a short\u2010chain fatty acid (SCFA) known for support in gastrointestinal (GI) health. Tributyrin (TB) could be used as an alternate source of butyrate. The objectives of this study were to encapsulate TB using gamma\u2010cyclodextrin (CD) by spray\u2010drying and to investigate the physicochemical and the fermentation properties of TB\/CD complex. The TB\/CD complex precipitated in water with an average stoichiometry of 1:1.3 of TB:CD. At a 1:2 molar ratio of TB:CD, TB was fully retained in the spray\u2010dried TB\/CD complex. The spray\u2010dried TB\/CD complex showed crystalline structure, supported by both X\u2010ray diffraction spectra and scanning electron microscopy images. The TB\/CD complex at 1:2 molar ratio was fermented and several SCFAs, including butyrate, were produced in an\n                      <jats:italic>in vitro<\/jats:italic>\n                      test using piglets\u2019 ileal and colonic contents. A dose\u2010dependent increase in the butyrate concentration in both ileum and ascending colon was observed. Approximately, 426 and 1189 \u03bcmole butyrate was produced per gram of TB\/CD powder at 9\u00a0mM treatment in ileum and ascending colon, respectively. Thus, the production of the TB\/CD complex using spray drying is feasible and the complex has the potential for food applications to improve intestinal health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>The findings in this study can be applied to produce encapsulated tributyrin with gamma\u2010cyclodextrin efficiently using spray\u2010drying. The TB\/CD complex was highly fermentable and caused an increase in the butyrate concentration in both ileum and ascending colon, which can be incorporated in foods to enhance butyrate delivery to the GI tract to assist gut health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15440","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T17:11:15Z","timestamp":1600276275000},"page":"2986-2993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Encapsulation of tributyrin by gamma\u2010cyclodextrin: Complexation, spray drying, and\n                    <i>in vitro<\/i>\n                    fermentation"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-0705","authenticated-orcid":false,"given":"Xueqian","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Food Science and Human Nutrition University of 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