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Plant material (dried roots) was subjected to methanol extraction at variable temperature (40 to 60\u00a0\u00b0C)\u00a0and time (12 to 36 hr) conditions as per two\u2010factorial design strategy, and responses in terms of antioxidant activity were determined. The optimized extraction conditions were found to be temperature of 60\u00a0\u00b0C and time of 36 hr. HPLC fingerprinting indicated the presence of coumarins in extract. To induce fibromyalgia, the mice were administered reserpine at a dose of 0.5\u00a0mg\/kg.\u00a0Mice were\u00a0orally treated with 100, 200, and 400\u00a0mg\/kg extract, and magnitude of fibromyalgia was quantified. In comparison to reserpine group, the extract treatment attenuated pain as shown by significant increase in paw withdrawal threshold against mechanical stimuli (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), improved motor ability indicated by increase in fall\u2010off time in inclined plane test (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), improved locomotion indicated by increased square crossings in open field test (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and improved cognition as shown by significant reduction in time to reach platform in Morris water maze test and passive avoidance task test (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Extract treatment significantly halted reserpine\u2010induced rise in serum cytokine level (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and brain oxidative stress (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                      <jats:italic>Angelica archangelica<\/jats:italic>\n                      extract exerted its beneficial effects in fibromyalgia possibly through the attenuation of oxidative stress\u2010mediated inflammatory cascade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>Leads from natural products have become an integral part of drug designing processes and have high acceptability due to their better tolerance. The optimization of extraction conditions of plant yields better results and could reduce the processing time, thus increasing its industrial value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15476","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T06:37:13Z","timestamp":1602571033000},"page":"3700-3710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Optimization of extraction conditions of\n                    <i>Angelica archangelica<\/i>\n                    extract and activity evaluation in experimental fibromyalgia"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-017X","authenticated-orcid":false,"given":"Anudeep","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research Punjabi University  Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet Singh","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Botanical and Environmental Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-7074","authenticated-orcid":false,"given":"Rajbir","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"issue":"12","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/ncprheum0349","article-title":"Mechanisms of disease: Genetics of fibromyalgia","volume":"2","author":"Ablin J. 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