{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:38:43Z","timestamp":1762191523275,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR5994\/FNS\/20\/563\/2012"],"award-info":[{"award-number":["BT\/PR5994\/FNS\/20\/563\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The study was conducted to investigate the efficacy of\n                      <jats:italic>Citrus maxima<\/jats:italic>\n                      (Pomelo) fruit segments fortified\n                      <jats:italic>paranthas<\/jats:italic>\n                      compared to pomelo juice and naringin in streptozotocin\u2010induced diabetic rats. The animals were divided into nine groups, Groups 1 to 3: negative control; Group 4: diabetic control; Groups 5 through 8: treatments with pomelo juice, naringin, plain\n                      <jats:italic>paranthas<\/jats:italic>\n                      , and pomelo supplemented\n                      <jats:italic>paranthas;<\/jats:italic>\n                      and Group 9 was positive control metformin. The groups were monitored for weight, oral glucose tolerance, insulin tolerance, bioavailability, biochemical parameters, and histopathological studies. Based on the result the group treated with\n                      <jats:italic>paranthas<\/jats:italic>\n                      fortified with pomelo fruit segment (Group 8) showed 19% of overall weight gain, approximately 50% reduction in plasma glucose level and improved serum protein (5.70\u00a0g\/dl)\u00a0and\u00a0serum\u00a0insulin (8.54\u00a0ng\/ml)\u00a0level\u00a0as\u00a0compared against diabetic control. The treatments had effectively lowered the level of liver enzyme and lipids (except HDL) in the serum along with the improved renal function. The group treated with pomelo juice and pomelo supplemented\n                      <jats:italic>paranthas<\/jats:italic>\n                      exhibited marked tolerance to the glucose and insulin similar to the positive control. Therefore, the antidiabetic activity was found to be more pronounced in the order of pomelo juice\u00a0&gt;\u00a0fortified\n                      <jats:italic>paranthas\u00a0<\/jats:italic>\n                      &gt;\u00a0naringin. Since pomelo juice is bitter and astringent in nature, the fruit can be better utilized in the form of fortified\n                      <jats:italic>paranthas<\/jats:italic>\n                      , which exerts antidiabetic effect similar to the positive control metformin. Hence,\n                      <jats:italic>paranthas<\/jats:italic>\n                      supplemented with pomelo fruit segments (bioactives\u2010rich) aids in the reducing the risk of diabetes and can be recommended to gain nutritional benefits for normal and diabetic populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15707","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:59:13Z","timestamp":1618621153000},"page":"2091-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of\n                    <i>Citrus maxima<\/i>\n                    fruit segment supplemented\n                    <i>paranthas<\/i>\n                    in STZ induced diabetic rats"],"prefix":"10.1111","volume":"86","author":[{"given":"Reshmi","family":"Somanathan Karthiga","sequence":"first","affiliation":[{"name":"Department of Fruit and Vegetable Technology CSIR\u2010Central Food Technological Research Institute  Mysuru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinde Vijay","family":"Sukhdeo","sequence":"additional","affiliation":[{"name":"Animal House Facility, Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysuru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Madhugiri Lakshminarayan","sequence":"additional","affiliation":[{"name":"Flour Milling, Baking and Confectionery Technology Department CSIR\u2010Central Food Technological Research Institute  Mysuru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4985-0562","authenticated-orcid":false,"given":"Shashirekha","family":"Mysuru Nanjarajurs","sequence":"additional","affiliation":[{"name":"Department of Fruit and Vegetable Technology CSIR\u2010Central Food Technological Research Institute  Mysuru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005603"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0168"},{"volume-title":"Theory and practice of histological techniques","year":"1996","author":"Bancroft D.","key":"e_1_2_10_4_1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20108741(01)00207\u20100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2013.10.007"},{"key":"e_1_2_10_7_1","first-page":"273","article-title":"Antidiabetic and hyperlipaemic effects of Citrus maxima Linn fruits on alloxan\u2010induced diabetic rats","volume":"2","author":"Bhandurge P.","year":"2010","journal-title":"International Journal of Drug Development & Research"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agg006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2007.07.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.04.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.17306\/J.AFS.2017.2017.0460"},{"key":"e_1_2_10_12_1","first-page":"175","article-title":"Effect of eugenia jambolana on streptozotocin\u2010nicotinamide induced type\u20102 diabetic nephropathy in rats","volume":"6","author":"Godwin S. 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