{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:38:21Z","timestamp":1782239901767,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703386"],"award-info":[{"award-number":["81703386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      25\u2010Hydroxylprotopanaxadiol\u20103\u03b2, 12\u03b2, 20\u2010triol (25\u2010OH\u2010PPD or AD\u20102) belongs to dammarane ginsenoside, and is commonly obtained from the acidic hydrolysate of total ginsensides of\n                      <jats:italic>Panax ginseng<\/jats:italic>\n                      . This study investigated the potential mechanism of AD\u20102 toward improving thioacetamide (TAA)\u2010induced hepatic fibrosis in mice. Mice were divided into seven groups: control group, TAA model group, TAA + AD\u20102 (5, 10, and 20\u00a0mg\/kg) groups, TAA + silymarin (100\u00a0mg\/kg) group, and TAA + Fu Fang Biejia (FFBj; 300\u00a0mg\/kg) group. All mice were treated to intraperitoneal TAA injection to establish a hepatic fibrosis model, and drugs were administered orally. The mechanism and related pathways underlying the AD\u20102\u2010mediated action against hepatic fibrosis were explored by Western blotting and immunohistochemical staining. After AD\u20102 treatment, the expression levels of Lipin\u20101, SREBP1, and F4\/80 significantly decreased, meanwhile the protein expressions levels of IL1\u03b2, IL1R1, IL18, Bax, Bid, Bcl\u20102, and cFlips also decreased. Furthermore, AD\u20102 inhibited RAF and MEK pathways. The results demonstrate that AD\u20102 can alleviate hepatic fibrosis. The mechanism is likely related to the regulation of lipid accumulation, inflammatory response, apoptosis pathway, and Raf\u2013MEK signaling pathways, which provide a basis for clinical research for the treatment of hepatic fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>Ginsenoside is one of the main active ingredients of ginseng, and can alleviate the symptoms of various diseases, for example, hepatic fibrosis. This paper mainly used Western blotting to explore its possible mechanism of action. The goal was to provide a reference for the development of traditional Chinese medicines for hepatic fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15731","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T23:37:29Z","timestamp":1619739449000},"page":"2753-2765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010hepatic fibrosis effects of AD\u20102 affecting the Raf\u2013MEK signaling pathway and inflammatory factors in thioacetamide\u2010induced liver injury"],"prefix":"10.1111","volume":"86","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Shenyang Pharmaceutical University  Shenyang 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