{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:29:20Z","timestamp":1787678960117,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773064"],"award-info":[{"award-number":["81773064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530056"],"award-info":[{"award-number":["31530056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972973"],"award-info":[{"award-number":["31972973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Hyperuricemia contributes to chronic kidney disease development. However, it has been historically viewed with limited research interest. In this study, we mimicked the development of hyperuricemic nephropathy by using a potassium oxonate\u2010induced hyperuricemia rat model. We found that administering vitamin C at 10\u00a0mg\/kg\/day effectively ameliorated hyperuricemic nephropathy. Compared to the control group, rats with hyperuricemia had significantly increased serum uric acid level, xanthine oxidase activity, and urine microalbumin level, by 5\u2010fold, 1.5\u2010fold, and 4\u2010fold, respectively. At the same time, vitamin C supplementation reverted these values by 20% for serum uric acid level and xanthine oxidase activity and 50% for microalbumin level. Vitamin C also alleviated renal pathology and decreased the expression of pro\u2010inflammatory and pro\u2010fibrotic markers. A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL\u20106\/JAK2\/STAT3 signaling pathway. Meanwhile, in macrophages, vitamin C inhibited the expression of TGF\u2010\u03b2, and reduced ROS level induced by MSU by about 35%. In short, our results suggest that vitamin C supplementation delay the progression of hyperuricemic nephropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15803","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T05:49:12Z","timestamp":1624427352000},"page":"3265-3276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis"],"prefix":"10.1111","volume":"86","author":[{"given":"Hongling","family":"Li","sequence":"first","affiliation":[{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Liu","sequence":"additional","affiliation":[{"name":"The China\u2010US (Henan) Hormel Cancer Institute  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee\u2010Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"The China\u2010US (Henan) Hormel Cancer Institute  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1493-8679","authenticated-orcid":false,"given":"Haitao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(02)00143-1"},{"key":"e_1_2_9_3_1","first-page":"2529569","article-title":"Antioxidant potential, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L. 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