{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:43:23Z","timestamp":1788295403474,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Exposure to ionizing radiation (IR) can cause oxidative damage to human body, leading to various diseases and even death. In this study, the potential radioprotective effect of coix seed seedling extract (CSS\u2010E) was studied through a model of\n                      <jats:sup>60<\/jats:sup>\n                      Co\u2010\u03b3 radiation\u2010induced oxidative stress in mice. Overall radioprotective effect of CSS\u2010E against radiation\u2010induced damage was evaluated by biochemical analysis and histopathological analysis. The results showed that CSS\u2010E could significantly reduce the IR\u2010induced damage to the hematopoietic system. CSS\u2010E\u2010M (200\u00a0mg\/kg BW) pretreatment could increase the activities of superoxide dismutase in serum, liver, and spleen increased by 31.68%, 45.10%, and 56.67%, respectively, and the glutathione peroxidase levels in serum, liver, and spleen of mice were improved by 19.17%, 41.97%, and 130.56%, respectively. Meanwhile, the glutathione levels of serum, liver, and spleen in CSS\u2010E\u2010M group were increased by 17.10%, 35.06%, and 40.71%, respectively. The contents of MDA in different tissues and serum could be reduced by CSS\u2010E\u2010M treatment to the normal level. Moreover, CSS\u2010E could markedly reduce the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in radiation mice, among which CSS\u2010E\u2010M group showed maximum restoration with decreased AST and ALT levels by 20.13% and 32.76% as compared against IR group. In conclusion, these results indicated that CSS\u2010E could be used as a potential natural radioprotectant against IR\u2010induced damage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.15991","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T10:44:37Z","timestamp":1639737877000},"page":"438-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective effect of coix seed seedling extract on\n                    <sup>60<\/sup>\n                    Co\u2010\u03b3 radiation\u2010induced oxidative stress in mice"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-6909","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou 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