{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:36:28Z","timestamp":1792636588478,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Kombucha has been gaining prominence around the world and becoming popular due to its good health benefits. This beverage is historically obtained by the tea fermentation of\n                      <jats:italic>Camellia sinensis<\/jats:italic>\n                      and by a biofilm of cellulose containing the symbiotic culture of bacteria and yeast (SCOBY). The other substrates added to the\n                      <jats:italic>C. sinensis<\/jats:italic>\n                      tea have also been reported to help kombucha production. The type as well as the amount of sugar substrate, which is the origin of SCOBY, in addition to time and temperature of fermentation influence the content of organic acids, vitamins, total phenolics, and alcoholic content of kombucha. The route involved in the metabolite biotransformation identified in kombucha so far and the microorganisms involved in the process need to be further studied. Some nutritional properties and benefits related to the beverage have already been reported. Antioxidant and antimicrobial activities and antidiabetic and anticarcinogenic effects are some of the beneficial effects attributed to kombucha. Nevertheless, scientific literature needs clinical studies to evaluate these benefits in human beings. The toxic effects associated with the consumption of kombucha are still unclear, but due to the possibility of adverse reactions occurring, its consumption is contraindicated in infants and pregnant women, children under 4\u2010years\u2010old, patients with kidney failure, and patients with HIV. The regulations in place for kombucha address a number of criteria, mainly for the pH and alcohol content, in order to guarantee the quality and safety of the beverage as well as to ensure transparency of information for consumers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16029","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T07:01:32Z","timestamp":1642143692000},"page":"503-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":218,"title":["Kombucha: A review of substrates, regulations, composition, and biological properties"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-9381","authenticated-orcid":false,"given":"Jeniffer Ferreira","family":"de Miranda","sequence":"first","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-3317","authenticated-orcid":false,"given":"Larissa Fernandes","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-6807","authenticated-orcid":false,"given":"C\u00edntia Borges","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-9274","authenticated-orcid":false,"given":"Thais Matsue","family":"Uekane","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-4787","authenticated-orcid":false,"given":"Kelly Alencar","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-502X","authenticated-orcid":false,"given":"Alice Gon\u00e7alves Martins","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2375-7455","authenticated-orcid":false,"given":"Fabr\u00edcio Freitas","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Paulista University  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-066X","authenticated-orcid":false,"given":"Adriene Ribeiro","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Pharmacy School Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100455"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106882\u201012\u201063"},{"key":"e_1_2_15_4_1","unstructured":"Australian Government Department of Health. 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