{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:05:06Z","timestamp":1773911106312,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials. In this study, polysaccharides were extracted from\n                      <jats:italic>Sphacelotheca sorghi<\/jats:italic>\n                      (Link) Clint. Monosaccharide composition of\n                      <jats:italic>S. sorghi<\/jats:italic>\n                      polysaccharides (SSP) was detected by high\u2010performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%). Type 2 diabetes (T2D) was induced by a high\u2010fat, high\u2010sugar diet\u2010fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated. After oral treatment of high dose of SSP (200\u00a0mg\/kg\/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control. Histopathological examination showed that SSP relieved liver damage. Furthermore, SSP regulated glucose and lipid metabolism by activating phosphoinositide 3\u2010kinase\/Akt signaling pathway. Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      For enhancing the utilization rate and economic value of an edible fungi\n                      <jats:italic>Sphacelotheca sorghi<\/jats:italic>\n                      (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids. The\n                      <jats:italic>S. sorghi<\/jats:italic>\n                      polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16091","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T09:38:46Z","timestamp":1646991526000},"page":"1882-1894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hypoglycemic and hypolipidemic effects of polysaccharide isolated from\n                    <i>Sphacelotheca sorghi<\/i>\n                    in diet\u2010streptozotocin\u2010induced T2D mice"],"prefix":"10.1111","volume":"87","author":[{"given":"Xin","family":"Fu","sequence":"first","affiliation":[{"name":"Food and Processing Research 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