{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:23:19Z","timestamp":1776288199705,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to determine the main bioactive components of\n                    <jats:italic>Cornus officinalis<\/jats:italic>\n                    vinegar (COV) and assess the effects of COV on the body weight (BW) and hepatic steatosis in a nonalcoholic fatty liver disease (NAFLD) mouse model. Seven\u2010week\u2010old KM female mice were divided into five treatment groups: (1) Normal control (NC) group, (2) high fat diet (HFD) group, (3) low concentration treatment group (3.5% COV), (4) medium concentration treatment group (5.0% COV), and (5) high concentration treatment group (6.5% COV). Mice in the NC group were fed with a normal chow diet, and those in the other four groups were fed with a HFD known for causing obesity for 10\u00a0weeks. Then, mice in the three COV treatment groups were orally administered with COV once a day for 6\u00a0weeks. Results showed that the contents of loganin and morroniside in COV reached 16.82 and 51.17\u00a0\u00b5g\/ml, respectively, and COV also contained multiple organic acids. COV significantly reduced BW, abdominal fat weight, liver weight, and the levels of glucose, triglyceride, and low\u2010density lipoprotein cholesterol of serum and increased the levels of high\u2010density lipoprotein cholesterol of serum (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). COV also improved the liver function and anti\u2010oxidant activity of liver (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). COV treatments increased the interleukin\u201010 expression and reduced the tumor necrosis factor\u2010\u03b1 expression in the liver tissue of NAFLD mice (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). Histopathological observation revealed that COV suppressed hepatic lipid accumulation and steatosis. The results suggest that COV may contribute to the alleviation of NAFLD and obesity.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.16178","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T03:21:10Z","timestamp":1654658470000},"page":"3248-3259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Cornus officinalis<\/i>\n                    vinegar reduces body weight and attenuates hepatic steatosis in mouse model of nonalcoholic fatty liver disease"],"prefix":"10.1111","volume":"87","author":[{"given":"Li","family":"Cao","sequence":"first","affiliation":[{"name":"College of Food and Bioengineering Henan University of Science and Technology  Luoyang Henan P.R. 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