{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:09:19Z","timestamp":1792174159238,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873097"],"award-info":[{"award-number":["81873097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Ginger extract (GE) and its major component 6\u2010gingerol (6G) have been reported to exert anti\u2010tumor effects in various cancers. The underlying mechanism, however, has not been well demonstrated. Here, we have focused on the relationship between promotion of mitochondrial biogenesis in tumor infiltrating CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells induced by GE and 6G and their cytotoxic effect. The results showed that GE induced 56% inhibition of tumor growth in Lewis lung carcinoma (LLC) xenograft mouse model and 6G induced 33% (25\u00a0mg\/kg) and 37% (50\u00a0mg\/kg) inhibition. GE increased mitochondrial mass of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells in tumor and draining lymph nodes (DLNs) significantly, while 6G had no significant effect. GE and 6G both had no significant influence on histopathological changes of liver and kidney in mice. In the co\u2010culture system of CTLL\u20102 cells and LLC cells, GE enhanced the cytotoxicity of CTLL\u20102 cells against LLC cells by 14% and 19% at concentrations of 2.5 and 5\u00a0mg\/ml, respectively. 6G did not promote cytotoxicity of CTLL\u20102 cells. GE increased mitochondrial mass at 5 and 10\u00a0mg\/ml and mtDNA copy number and ATP production at 2.5, 5, 10\u00a0mg\/ml in CTLL\u20102 cells. 6G promoted mtDNA copy number at 50, 100, 150 \u00b5M and mitochondrial mass and ATP production at 25, 50, 100, 150 \u00b5M in CTLL\u20102 cells. These results suggest that promotion of mitochondrial biogenesis and function in tumor infiltrating CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells may play an essential role in GE\u2010induced inhibition of tumor growth. The current results perfect the mechanism of anti\u2010tumor effect of ginger, which is beneficial for further application in cancer management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      Ginger, as a worldwide food seasoning and herbal medicine in traditional Chinese medicine, has been reported to possess anti\u2010tumor efficacy. To our knowledge, it is the first time to focus on ginger's ability of promoting mitochondrial biogenesis in tumor infiltrating CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells to explore the mechanism of its anti\u2010tumor effect. Our observations demonstrate that ginger inhibits tumor growth via promoting mitochondrial biogenesis and function of T cells. The present study links food to anti\u2010tumor immunity and provides impetus to investigate and design dietary supplements for cancer management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16228","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T07:32:37Z","timestamp":1655364757000},"page":"3307-3317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of ginger extract and its major component 6\u2010gingerol on anti\u2010tumor property through mitochondrial biogenesis in CD8\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1111","volume":"87","author":[{"given":"Xiaohong","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-9545","authenticated-orcid":false,"given":"Jianhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126605"},{"issue":"11","key":"e_1_2_8_3_1","first-page":"767","article-title":"Anticancer and antioxidant activity of Zingiber officinale Roscoe rhizome","volume":"54","author":"Ansari J. 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