{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:41:10Z","timestamp":1787884870591,"version":"build-2784847793"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Despite the global preference for green extraction methods in the recovery of plant bioactives,\n                      <jats:italic>Tetrapleura tetraptera<\/jats:italic>\n                      fruit polyphenols (TTP) are yet to receive considerable attention. For the first time, pressurized hot water extraction (PHWE) of TTP was optimized for total phenol content (TPC) and antioxidant activity (AA) using the Box Behnken design of response surface methodology. Predictor variables were time, temperature, and liquid\u2010to\u2010solid ratio. An optimum solution with a desirability of 0.805 was selected and parameters were 43\u00a0min, 220\u00b0C, and 60\u00a0ml g\n                      <jats:sup>\u22121<\/jats:sup>\n                      liquid\u2010to\u2010solid ratio, yielding TPC of 8.92\u00a0mg gallic acid equivalent per gram of sample on dry weight basis (GAE g\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00a0dw\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and AA of 70.35%. Purified, optimized TTP were characterized and quantified using HPLC\/LC\u2010MS. PHWE mainly extracted rutin (379.04\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), cyanidin\u20103\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010glucoside (chloride) (299.55\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), naringenin 7\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010glucoside (240.11\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ),\n                      <jats:italic>p<\/jats:italic>\n                      \u2010coumaric acid (177.28\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), isorientin (150.43\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and gallic acid (118.06\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) whereas cyanidin\u20103\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010glucoside (chloride) (83.27\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), protocatechuic acid (61.37\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), rutin (28.03\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and gallic acid (22.62\u00a0\u00b5g g\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) were mainly extracted by hot water extraction, which was a control. PHWE\u2010obtained TTP showed higher cellular antioxidant activity, cytotoxicity in human liver cancer cell lines (HepG2), and antimicrobial property against\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      ,\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      , and\n                      <jats:italic>Bacillus subtilis<\/jats:italic>\n                      than control. The potential mechanisms underlying the biological activities of some of the major polyphenols extracted were briefly discussed. Considering the wide use of the\n                      <jats:italic>T. tetraptera<\/jats:italic>\n                      (TT) fruit in Africa in foods and medicine, the use of more efficient green extraction methods such as PHWE is recommended.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      This study serves as a baseline for optimizing pressurized hot water extraction, purification, identification, and quantification of\n                      <jats:italic>Tetrapleura tetraptera<\/jats:italic>\n                      polyphenols (TTP) and their biological activities, being the first of its kind. The varied biological effects shown can be exploited further for applications of TTP as nutraceutical agents and preservatives in foods in different forms. Also, the high amounts of gallic acid and other phenolic acids and flavonoids confirmed in this study make TTP good candidates for the development of metal\u2013phenol network nanoparticles to enhance adequate solubility and distribution in food systems in light of the above proposed applications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16422","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T08:13:07Z","timestamp":1671178387000},"page":"175-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Optimized pressurized hot water extraction, HPLC\/LC\u2010MS characterization, and bioactivity of\n                    <i>Tetrapleura tetraptera<\/i>\n                    L. dry fruit polyphenols"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-8639","authenticated-orcid":false,"given":"Courage Sedem","family":"Dzah","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Applied Sciences and Technology Ho Technical University  Ho Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3923\/jm.2006.416.422"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJPR\/2016\/26554"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02762"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10496475.2011.560087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.02.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2007.08.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.01.048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.15414\/jmbfs.3550"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.12980\/APJTB.4.2014C73"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2014.964.977"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA01911G"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v12i2.30892"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.02.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051061"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.18697\/ajfand.67.13600"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109598"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100719"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01496395.2019.1675704"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100547"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2022.100093"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.9734\/AJMAH\/2016\/29362"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.15761\/RRI.1000165"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.08.724"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2017.03.007"},{"issue":"1","key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/bbrj.bbrj_150_19","article-title":"Antidermatophyte activity of Syzygium aromaticum, Petroselinum crispum, and Tetrapleura tetraptera","volume":"4","author":"Fokouo R. 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