{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:41:55Z","timestamp":1789036915514,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Among natural products with sleep\u2010promoting activity, hops have been used since ancient times as a tranquilizer and hypnotic agent. This study investigated the sleep\u2010promoting effects of extracts of various hop (\n                    <jats:italic>Humulus lupulus<\/jats:italic>\n                    L.) varieties in invertebrate and vertebrate models. The content of \u03b1\u2010acids, \u03b2\u2010acids, and xanthohumol was higher in hop 70% alcohol extracts than in hop hot water extracts. Among the alcohol extracts, Citra contained a high \u03b1\u2010acid content (229.32\u00a0\u00b5g\/mg), while Saphir showed high \u03b2\u2010acid and xanthohumol content (66.37 and 4.23\u00a0\u00b5g\/mg, respectively). In\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , Simcoe and Mosaic water extracts and Saphir and Simcoe alcohol extracts significantly increased total nighttime sleep. Total sleep time of mice with pentobarbital\u2010induced sleep was significantly increased by Simcoe and Mosaic water extracts and Saphir and Simcoe ethanol extracts compared to the normal group. Oral administration of Simcoe water extract and Saphir alcohol extract improved sleep in the caffeine\u2010induced insomnia model and upregulated the mRNA expression of GABA\n                    <jats:sub>A<\/jats:sub>\n                    (gamma 2 subunit) and GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptors in mouse brains. Additionally, Saphir alcohol extract significantly increased the GABA content in mouse brains. Simcoe water extract and Saphir ethanol extract modulated GABAergic signaling to improve sleep\u2010related behaviors, including sleep duration.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.16544","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T03:58:50Z","timestamp":1681185530000},"page":"2217-2228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chemical compositions and sleep\u2010promoting activities of hop (\n                    <i>Humulus lupulus<\/i>\n                    L.) varieties"],"prefix":"10.1111","volume":"88","author":[{"given":"Byungjick","family":"Min","sequence":"first","affiliation":[{"name":"Department of Integrated Biomedical and Life Science, Graduate School Korea University  Seoul Republic of Korea"},{"name":"Lotte R&amp;D Center  Seoul Republic of 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