{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:14:39Z","timestamp":1782321279065,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Accumulating evidence suggests that specific probiotic strains exert hypoglycemic effects on type 2 diabetes mellitus (T2DM), and probiotic strains within\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      exhibit potential beneficial effects on T2DM. In this study, \u03b1\u2010glucosidase inhibitory activities of 14\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      strains were assessed in vitro. The hypoglycemic effects of\n                      <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      WHH2270 with high \u03b1\u2010glucosidase inhibitory activity (42.03%) were then investigated in a high\u2010fat diet\/streptozotocin\u2010induced T2DM rat model. Oral administration of WHH2270 (4 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      CFU\/kg\/day) for 8\u00a0weeks significantly reversed the reduced body weight and ameliorated the levels of fasting blood glucose, serum triglyceride, serum total cholesterol, glucose tolerance, and insulin resistance in T2DM rats. Using 16S rRNA high\u2010throughput sequencing of feces, WHH2270 was revealed to reshape the gut microbiome composition by increasing the abundances of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      and decreasing the abundances of\n                      <jats:italic>UCG_005<\/jats:italic>\n                      ,\n                      <jats:italic>Clostridium<\/jats:italic>\n                      , and\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      in T2DM rats. Besides, the fecal levels of short\u2010chain fatty acids (SCFAs) including acetate, propionate, and butyrate were also elevated after WHH2270 administration. Moreover, the gene expressions of SCFA receptors\n                      <jats:italic>FFAR2<\/jats:italic>\n                      and\n                      <jats:italic>FFAR3<\/jats:italic>\n                      in the colon and pancreas of T2DM rats were restored by WHH2270 administration, accompanied by increased levels of serum acetate. In summary, these results provide evidence that WHH2270 has the potential to improve T2DM symptoms by alleviating hyperglycemia, which was associated with changes in the gut microbiome composition and SCFA production.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      WHH2270 with high \u03b1\u2010glucosidase inhibitory activity may serve as a promising hypoglycemic agent for the treatment of T2DM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16727","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T10:39:56Z","timestamp":1691404796000},"page":"3967-3983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Oral administration of\n                    <i>Bifidobacterium longum<\/i>\n                    WHH2270 ameliorates type 2 diabetes in rats"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-3999","authenticated-orcid":false,"given":"Kan","family":"Gao","sequence":"first","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd Hangzhou P. 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