{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:14:16Z","timestamp":1791317656502,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Food allergy (FA) is acknowledged as a significant public health and food safety issue, due to its manifestation as an amplified immune reaction to food antigens. Recently, probiotics within\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      have been highlighted as a promising strategy against allergic disease by modulating the balance of Th1\/Th2 responses. However, the allergy\u2010alleviating effects of probiotic\n                      <jats:italic>Leuconostoc mesenteroides<\/jats:italic>\n                      strains are unknown. Therefore, this study investigated the potentials of eleven\n                      <jats:italic>L. mesenteroides<\/jats:italic>\n                      strains on the Th1\/Th2 balance in vitro by evaluating the expression patterns of interferon\u2010gamma (IFN\u2010\u03b3) (Th1 cytokine) and interleukin\u20104 (IL\u20104) (Th2 cytokine) in mesenteric lymph node\u2010derived lymphocytes from ovalbumin (OVA)\u2010sensitized mice. Among strains, WHH1141 incubation caused the highest IFN\u2010\u03b3\/IL\u20104 ratio. Oral administration of WHH1141 (1\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \u00a0CFU\/mL) in the OVA\u2010induced FA mouse model for 40 days improved the weight loss and FA pathological symptoms and normalized the serum immunoglobulin E levels. Meanwhile, the OVA\u2010induced elevated gene expressions of cytokines (\n                      <jats:italic>IL\u20104<\/jats:italic>\n                      ,\n                      <jats:italic>IL\u20105<\/jats:italic>\n                      , and\n                      <jats:italic>IL\u201013<\/jats:italic>\n                      ) and tight\u2010junction proteins (\n                      <jats:italic>ZO\u20101<\/jats:italic>\n                      and\n                      <jats:italic>Occludin<\/jats:italic>\n                      ) and levels of cytokines (IL\u20104, IL\u20105, and IL\u201013) and histamine in the jejunum were restored by WHH1141. Furthermore, WHH1141 reversed the reduced gut microbial diversity and short\u2010chain fatty acid (SCFA) levels, specifically increased Bacteroidota abundance, and decreased Firmicutes abundance in OVA\u2010induced mice. Overall, these findings suggest that WHH1141 exerts FA\u2010alleviating effects on OVA\u2010induced mice, which is involved with the inhibition of the jejunal Th2 immune responses and the modulation of gut microbiome composition and SCFA productions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Leuconostoc mesenteroides<\/jats:italic>\n                      WHH1141 with FA\u2010alleviating potentials may be considered a promising approach in the mitigation of FA symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.16760","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T02:53:30Z","timestamp":1694141610000},"page":"4289-4304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Leuconostoc mesenteroides<\/i>\n                    WHH1141 ameliorates ovalbumin\u2010induced food allergy in mice"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-3999","authenticated-orcid":false,"given":"Kan","family":"Gao","sequence":"first","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Fan","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Li","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Development Department Hangzhou Wahaha Group Co., Ltd  Hangzhou P. R. China"},{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010018\u20108710\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8063647"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.108947"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.10.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235155"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u201000845\u20106"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010022\u201001094\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255747"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2022.0052"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo03723d"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10051020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2022.09.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1973835"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.01.034"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.02.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948\u2010020\u201000120\u2010x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.04.070"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104286"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29751"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo03520g"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.02.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120006916"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.06348\u201011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2005.02362.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2161271"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322830"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010021\u201001201\u20108"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2018_316"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1946369"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1708.08051"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.047"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020318"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2021.101095"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07482"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo03371e"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132762"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.630294"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.16760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:47:57Z","timestamp":1762195677000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.16760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/1750-3841.16760"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.16760","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,7]]},"assertion":[{"value":"2023-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}