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In this study, the potential allergenicity of enzymatically hydrolyzed casein (HC) was evaluated based on in vitro and in vivo. The results showed that Alcalase and Protamex treatment (AT, PT) reduced the potential allergenicity of CN, with the greatest reductions of 68.25% and 50.75%, respectively. In addition, in vivo results showed that HC effectively alleviated allergic response symptoms of Balb\/c mice; a significant tendency toward decreased serum IgG1 and mast cell tryptase levels was observed, accompanied by a decrease of Th2\u2010associated IL\u20104, IL\u20105, and IL\u201013 and an increase of IFN\u2010\u03b3 levels in spleen. Moreover, the inflammation of the lung, jejunum, and ileum was remarkably ameliorated. The findings indicated that HC induced a shift toward Th1 response and maintained the Th1\/Th2 immune balance. Importantly, our results provide the basis for the production of hypoallergenic dairy products.<\/jats:p>","DOI":"10.1111\/1750-3841.17032","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T04:34:34Z","timestamp":1712032474000},"page":"3037-3047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of the potential allergenicity of enzymatically hydrolyzed casein in Balb\/c mouse model"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-7742","authenticated-orcid":false,"given":"Xiaona","family":"Liang","sequence":"first","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Regional Modern Agriculture &amp; Environmental Protection, Huaiyin Normal University, Jiangsu Key Laboratory for Food Safety &amp; Nutrition Function Evaluation Huaiyin Normal University  Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezhi","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute Bright Dairy &amp; Food Co., Ltd.  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