{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:12:10Z","timestamp":1790946730414,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Polysaccharides from natural sources can regulate the composition of intestinal flora through the \u201cgut\u2010liver axis\u201d pathway, potentially ameliorating alcoholic liver injury.\n                      <jats:italic>Aspalathus linearis<\/jats:italic>\n                      , also known as rooibos, is one such natural product that has shown promise in this regard. This study looked at the structural properties of\n                      <jats:italic>A. linearis<\/jats:italic>\n                      polysaccharide (ALP) and how well it would work to treat acute alcoholic liver impairment. This study looks at the composition of monosaccharides, functional groups, and molecular weight (Mw) of a newly discovered water\u2010soluble polysaccharide, named ALP. The polysaccharide is composed of pyranose rings, amide groups, and sulfate groups linked by \u03b2\u2010glycosidic linkage. It has a relative Mw of 4.30\u00a0\u00d7\u00a010\n                      <jats:sup>3<\/jats:sup>\n                      \u00a0kDa and is composed of glucose, rhamnose, and some other monosaccharides. The study found that treating mice with the model of acute alcoholic liver disease with ALP could alleviate pathological symptoms, inhibit the release of inflammatory cytokines, and suppress indicators of oxidative stress. Experiments have shown that different doses of ALP can activate the P4502E1\/Keap1\u2010Nrf2\u2010HO\u20101 signaling pathway. The regulation of inflammatory factors and downstream antioxidant enzymes occurs as a result. Based on these data, it is likely that ALP protects the liver via the \u201cgut\u2010liver axis\u201d pathway by reducing oxidative stress\u2010related damage, inflammation, and alcohol\u2010related alterations to the gut microbiome. The results indicate that ALP mitigates injury caused by oxidative stress, inflammatory responses, and changes in the gut microbiota induced by alcohol through the \u201cgut\u2010liver axis\u201d pathway, which provides protection to the liver. This provides preliminary evidence for the development of related drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      Researchers extracted a polysaccharide from fresh leaves of\n                      <jats:italic>Auricularia auricula<\/jats:italic>\n                      . The polysaccharide was purified and determined to have a predominantly homogeneous molecular weight. An acute alcoholic liver damage mouse model was established, and it was concluded that the polysaccharide could ameliorate liver injury in mice through the \u201cgut\u2010liver axis\u201d pathway. This novel polysaccharide can be used as an additive to develop functional foods with beneficial effects, which can positively impact the daily maintenance of consumers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17055","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T10:49:57Z","timestamp":1716979797000},"page":"4535-4550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Structural characterization of\n                    <i>Aspalatus linearis<\/i>\n                    polysaccharide and its improving effect on acute alcoholic liver injury"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-2174","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhong","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. 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