{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:03:03Z","timestamp":1782226983687,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Currently,\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , and\n                      <jats:italic>Streptococcus thermophilus<\/jats:italic>\n                      (BLS) are widely recognized as the crucially beneficial bacteria in the gut. Many preclinical and clinical studies have shown their protective effects against non\u2010alcoholic fatty liver disease (NAFLD). However, whether gestational BLS supplementation could alleviate NAFLD in the offspring is still unknown. Kunming mice were given a high\u2010fat diet (HFD) for 4\u00a0weeks before mating. They received BLS supplementation by gavage during pregnancy. After weaning, offspring mice were fed with a regular diet up to 5 weeks old. Gestational BLS supplementation significantly increased the abundance of\n                      <jats:italic>Actinobacteriota<\/jats:italic>\n                      ,\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      in the gut of dams exposed to HFD. In offspring mice exposed to maternal HFD, maternal BLS intake significantly decreased the ratio of\n                      <jats:italic>Firmicutes<\/jats:italic>\n                      to\n                      <jats:italic>Bacteroidetes<\/jats:italic>\n                      as well as the relative abundance of\n                      <jats:italic>Prevotella<\/jats:italic>\n                      and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      , but increased the relative abundance of\n                      <jats:italic>Parabacteroides<\/jats:italic>\n                      . In offspring mice, maternal BLS supplementation significantly decreased the hepatic triglyceride content and mitigated hepatic steatosis. Furthermore, maternal BLS supplementation increased the glutathione content and reduced malondialdehyde content in the liver. In addition, mRNA and protein expression levels of key rate\u2010limiting enzymes in mitochondrial \u03b2\u2010oxidation (CPT1\u03b1, PPAR\u03b1, and PGC1\u03b1) in the livers of offspring mice were significantly increased after gestational BLS supplementation. Thus, gestational BLS supplementation may ameliorate maternal HFD\u2010induced steatosis and oxidative stress in the livers of offspring mice by modulating fatty acid \u03b2\u2010oxidation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17056","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T09:08:55Z","timestamp":1712308135000},"page":"3064-3077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gestational supplementation of\n                    <i>Bifidobacterium<\/i>\n                    ,\n                    <i>Lactobacillus<\/i>\n                    , and\n                    <i>Streptococcus thermophilus<\/i>\n                    attenuates hepatic steatosis in offspring mice through promoting fatty acid \u03b2\u2010oxidation"],"prefix":"10.1111","volume":"89","author":[{"given":"Hangjun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Liwan District Maternal and Child Health Hospital  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Guangzhou Customs  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Guangzhou Customs  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-7054","authenticated-orcid":false,"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine Jinan University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2018.02.009"},{"issue":"9","key":"e_1_2_9_3_1","first-page":"1090","article-title":"Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: A double blind randomized clinical trial","volume":"15","author":"Aller R.","year":"2011","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020640"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511004491"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.846873"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001422"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.997018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.08.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100061\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1107071"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030598"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0129"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0398"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12506"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1712984"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010021\u201001440\u2010w"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17096"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200387"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010011\u20101887\u20104"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00300\u201015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.134"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i2.274"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43300"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20683"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.039"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.09.011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00165\u20100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106348"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6836"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121151"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006929\u20100"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15020284"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4142"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0365"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo02905b"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010328970"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1129904"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.78"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.17056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.17056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.17056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:23:48Z","timestamp":1781875428000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.17056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1750-3841.17056"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.17056","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}