{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:36:30Z","timestamp":1774694190957,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Calcium supplementation has been shown to be efficacious in mitigating the progression of senile osteoporosis (SOP) and reducing the incidence of osteoporotic fractures resulting from prolonged calcium shortage. In this study,\n                    <jats:italic>Grifola frondosa<\/jats:italic>\n                    (GF) peptides\u2010calcium chelate were synthesized through the interaction between peptide from GF and CaCl\n                    <jats:sub>2<\/jats:sub>\n                    . The chelation reaction was shown to involve the participation of the amino and carboxyl groups in the peptide, as revealed by scanning electron microscope, Fourier\u2010transform infrared, and ultraviolet spectrophotometry. Furthermore, a mouse model of (SOP) induced by\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose was established (SCXK\u20102018\u20100004). Results demonstrated that low dosage of low\u2010molecular weight GF peptides\u2010calcium chelates (LLgps\u2010Ca) could significantly improve serum index and pathological features of bone tissue and reduce bone injury. Further research suggested that LLgps\u2010Ca could ameliorate SOP by modulating the disrupted metabolic pathway, which includes focal adhesion, extracellular matrix receptor interaction, and PI3K\u2010Akt signaling pathway. Using Western blot, the differentially expressed proteins were further confirmed. Thus, calciumchelating peptides from GF could serve as functional calcium agents to alleviate SOP.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.17073","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T03:14:07Z","timestamp":1714446847000},"page":"3816-3828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Positive effect of peptide\u2010calcium chelates from\n                    <i>Grifola frondosa<\/i>\n                    on a mouse model of senile osteoporosis"],"prefix":"10.1111","volume":"89","author":[{"given":"Yu","family":"Xiong","sequence":"first","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Ru","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Zhi","family":"Peng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-3093","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University  Fuzhou Fujian China"},{"name":"College of Food Science Fujian Agriculture and Forestry University  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Na","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology Fujian 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