{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:02:41Z","timestamp":1771027361076,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017421","name":"Toyo Suisan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Dietary factors, particularly proteins, have been extensively explored to combat cognitive impairment. We have previously reported that dietary fish (Alaska Pollock) protein (APP) is more effective than casein (CAS) or fish oil in maintaining short\u2010term memory in senescence\u2010accelerated mice prone 10 (SAMP10). To examine the specificity of the protective effect of APP intakes against short\u2010term memory decline, we assessed the impact of various dietary animal proteins, including APP, CAS, chicken breast protein (CP), and whey protein (WP), against age\u2010related cognitive function in SAMP10 mice. After feeding the experimental diets for 5 months, memory was assessed using the Y\u2010maze. The APP group exhibited a significant increase in spontaneous alternation behavior as an indicator of working memory when group compared with groups fed with other protein source. Additionally, the APP group displayed significantly higher neurofilament heavy chain positivity than the CAS and CP groups, as evidenced immunohistochemical analysis. Gut microbiota analysis indicated that dietary APP significantly enhanced the relative abundance of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , which positively correlated with spontaneous alternation behavior. Collectively, these findings suggest that dietary APP is more effective than CAS, CP, or WP in preventing age\u2010related short\u2010term memory decline and morphological abnormalities in the hippocampal axons of SAMP10 mice. Moreover, APP\u2010mediated improvements in cognitive deficits may be associated with changes in microbiota diversity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>This research suggests that dietary fish protein from Alaska Pollock may be more efficient in prevention short\u2010term memory decline in mice, compared to other animal proteins. This finding has practical implications for nutritional optimization, developing the new health food products, and elucidating the relationship between the impact of specific proteins on gut microbiota and prevention of age\u2010related cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17119","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T11:35:16Z","timestamp":1716204916000},"page":"3776-3787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring animal protein sources against prevent age\u2010related short\u2010term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects"],"prefix":"10.1111","volume":"89","author":[{"given":"Yuki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health Kansai Medical University  Hirakata Osaka 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