{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:24:15Z","timestamp":1773789855058,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Study on the hypolipidemic effect of turmeric combined with hawthorn on C57BL\/6 obese mice and its possible mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>C57 mice were fed with 60% high\u2010fat diet for 8 weeks to establish an obesity model, and 4 mice were slaughtered to verify whether the modeling was successful. The successful mice were divided into model group (HFD), positive group (high fat feed group [HFD]\u00a0+\u00a0simvastatin group [SIM]), turmeric group (HFD\u00a0+\u00a0TUR), hawthorn group (HFD\u00a0+\u00a0HAW), and para\u2010medicine group (HFD\u00a0+\u00a0para\u2010drug group [DOU]) for 4 weeks by gavage intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Different intervention groups had certain lipid\u2010lowering effects, and the para\u2010medicine group showed significant differences (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) in reducing serum total cholesterol, triglycerides, low\u2010density lipoprotein cholesterol, glutamic acid transaminase (ALT), glutamic acid transaminase (AST), and increasing high\u2010density lipoprotein cholesterol. In the para\u2010medicine group, the protein expression of peroxisome proliferator\u2010activated receptor \u03b3, fatty acid synthase, platelet\u2010reactive protein receptor 36, and CCAAT\/enhancer binding protein \u03b1 were significantly downregulated, and the protein expression of carnitine palmitoyl transferase1 and peroxisome proliferator\u2010activated receptor \u03b1 protein expression (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001), thus suggesting that turmeric and hawthorn are superior to turmeric and hawthorn alone in enhancing lipid metabolism\u2010related mechanisms. Combined effects of turmeric and hawthorn improve lipid metabolism in mice, protect the liver, and improve the protein expression of liver\u2010related genes. This study can lay the theoretical basis for the future association of medicinal food products and the development of related weight loss products.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17123","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T09:45:39Z","timestamp":1716889539000},"page":"4493-4504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation on the lipid\u2010lowering effect and mechanism by combining turmeric with hawthorn in C57BL\/6 obese mice"],"prefix":"10.1111","volume":"89","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"School of Tea and Food Science &amp; Technology Anhui Agricultural University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-3090","authenticated-orcid":false,"given":"Zongwei","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajian","family":"Xu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Speciality Food Co\u2010Built by Sichuan and Chongqing, College of Food Science Southwest University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Tea and Food Science &amp; Technology Anhui Agricultural University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12525"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02625B"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20204"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.878305"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.02.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead053"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945011793591626"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154090"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100741"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112150"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.53771\/ijbpsa.2023.5.2.0049"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"180","article-title":"Qualitative and quantitative profile of curcumin from ethanolic extract of Curcuma longa","volume":"2","author":"Himesh S.","year":"2011","journal-title":"International Research Journal Of Pharmacy"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-014-9542-4"},{"key":"e_1_2_9_15_1","volume-title":"Tyrosine phosphorylation of the RUNX1 transcription factor by Src kinase activates C\/EBP\u2010alpha in granulopoiesis","author":"Leong W. 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