{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:12:01Z","timestamp":1792174321892,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2101504"],"award-info":[{"award-number":["2021YFC2101504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21706213"],"award-info":[{"award-number":["21706213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sulforaphane\u2010loaded nanoparticles (NP\u2010SF) were prepared in this study to improve their biological effects. Based on propylene glycol alginate and zein as wall materials and anthocyanin and CaCl\n                    <jats:sub>2<\/jats:sub>\n                    as crosslinking agents, the NPs were encapsulated by the crosslinking method and freeze\u2010dried. With the increasing contents of anthocyanin and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , the encapsulation efficiency and loading capacity of NP\u2010SF were both increased. In vitro simulated digestion experiments showed controlled release of SF from the NPs. The pharmacokinetics confirmed that NP\u2010SF exerted a slower release effect in rats, with improved SF bioavailability and protective effects on liver injury induced by\n                    <jats:italic>N<\/jats:italic>\n                    \u2010diethylnitrosamine in mice. NP\u2010SF reduced serum indicators of liver injury, increased the activities of antioxidant enzymes and GSH levels, and reduced malondialdehyde levels in the liver. In addition, SF activated the Keap1\/Nrf2 signaling pathway and upregulated the expression of the Nrf2 downstream genes NQO1 and heme oxidase 1. High doses of NP\u2010SF, in particular, had a higher therapeutic effect. In conclusion, encapsulation enhanced the biological activity of SF and promoted physiological function.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.17156","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T23:09:03Z","timestamp":1725232143000},"page":"6707-6719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sulforaphane nanoparticles coated with zein\u2010propylene glycol alginate attenuate\n                    <i>N<\/i>\n                    \u2010diethylnitrosamine\u2010induced liver injury in mice"],"prefix":"10.1111","volume":"89","author":[{"given":"Qilei","family":"Wang","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Northwest University Xi'an P. R. 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