{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:28:51Z","timestamp":1785306531963,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Depression is one of the most common psychiatric conditions worldwide, with an annual escalation in prevalence. The serotonin (5\u2010Hydroxytryptamine [5\u2010HT]) metabolism through the gut\u2013brain axis has been revealed to be related to the development of depression. Our previous study demonstrated that\n                      <jats:italic>Lactococcus lactis<\/jats:italic>\n                      WHH2078 alleviated depression in mice by shaping the gut microbiome composition and 5\u2010HT metabolism. However, little research has explored the synergistic effects of probiotics and natural mental health\u2010improving products. In this study, three natural products (saffron,\n                      <jats:sc>l<\/jats:sc>\n                      \u2010theanine, and phosphatidylserine), either individually or in combination, were orally administrated for 4 weeks in chronic restraint stress (CRS)\u2010induced mice, and their depressive behaviors, hippocampal 5\u2010HT, and serum corticosterone were assessed. Saffron demonstrated improvement of the depressive\u2010like behaviors via multiple behavioral tests and reversed the declined concentration of 5\u2010HT and increased concentration of corticosterone. Following an initial screening, saffron was chosen to be combined with WHH2078, referred to as WHHMOOD\u2122. Furthermore, the effects of WHHMOOD were evaluated in mice with depressive\u2010like behaviors. WHHMOOD reduced immobility time in the forced swimming test and tail suspension test, increased the time spent in the central area in open field test, and reduced the serum corticosterone level. Besides, WHHMOOD improved the CRS\u2010induced gut microbial dysbiosis by reversing gut microbial diversity and the abundances of\n                      <jats:italic>Ligilactobacillus, Candidatus Arthromitus<\/jats:italic>\n                      , and\n                      <jats:italic>Erysipelatoclostridium<\/jats:italic>\n                      . Compared to WHH2078, WHHMOOD treatment significantly increased the travel distance and hippocampal 5\u2010HT level in mice. In conclusion, WHHMOOD exhibited prophylactic effects on depressive\u2010like in CRS mice, which may act as a promising agent for improving the symptoms of depression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17289","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T15:34:33Z","timestamp":1723304073000},"page":"5912-5927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prophylactic effects of supplementation of a combination of\n                    <i>Lactobacillus lactis<\/i>\n                    WHH2078 and saffron on depressive\u2010like behaviors in mice exposed to chronic stress"],"prefix":"10.1111","volume":"89","author":[{"given":"Cailing","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Food and Biological Engineering of Zhejiang Province  Hangzhou P. R. 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