{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:48:46Z","timestamp":1781545726456,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Currently, most studies focus on the functions of probiotic\u2010fermented milk, whereas there are relatively few studies on the function of postbiotic\u2010fermented milk in relieving constipation. In this study, we aimed to assess the modulation of constipation symptoms and its mechanism of action by different concentrations of\n                    <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                    \u2010fermented milk as a postbiotic in a loperamide hydrochloride\u2010induced constipation model in BALB\/c mice. By comparing the relevant indexes, colon histological analysis, gene expression level, and intestinal flora structure in the constipation model of mice, we found that high and ultra\u2010high doses of fermented milk can effectively relieve constipation. Fermented milk effectively reduced defecation time, increased the rate of small intestinal propulsion in constipated mice, and alleviated colonic inflammation, safeguarding the normal function of the intestinal tract. In addition, it can regulate the intestinal flora, downregulate the abundance of\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    , upregulate the abundance of species of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    and\n                    <jats:italic>Actinobacteriota<\/jats:italic>\n                    , and improve the overall abundance level of intestinal flora in mice.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.17338","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T22:55:14Z","timestamp":1725231314000},"page":"6733-6744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of\n                    <i>Lacticaseibacillus paracasei<\/i>\n                    fermented milk on a model of constipation induced by loperamide hydrochloride in BALB\/c mice"],"prefix":"10.1111","volume":"89","author":[{"given":"Cheng","family":"Xue","sequence":"first","affiliation":[{"name":"Hunan Haoyiduo Dairy Co., Ltd  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Market Supervision and Administration Service Center of Lijin County  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[{"name":"Dongying Yidayao Dairy Co., Ltd  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Haoyiduo Dairy Co., Ltd  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-5856","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou 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