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This fruit also possesses high nutritional value, with a range of bioactive compounds known to confer potential health benefits and prevent chronic diseases, such as diabetes, which makes it useful for use as pharmaceutical agents and dietary supplements. In order to improve its technological and biological effects, a concentration will be required. Thus, the microfiltration, followed by vacuum concentration, can be an interesting strategy for this purpose. This study aimed to explore tangential microfiltration to produce microfiltered material, which is an important step to obtain the microfiltered red\u2010purple pitaya concentrate. Therefore, physicochemical and chemical characterization (including\n                      <jats:sup>1<\/jats:sup>\n                      H NMR analysis) and biological properties (toxicity and diabetes) of this concentrate were assessed, using adult zebrafish as a model. The results show that microfiltration was carried out efficiently, with an average consumption of 95.75\u00a0\u00b1\u00a03.13 and 74.12\u00a0\u00b1\u00a03.58\u00a0kW h m\n                      <jats:sup>\u22123<\/jats:sup>\n                      , varying according to the material used (\u201cunpeeled pitaya pulp\u201d or \u201cpitaya pulp with peel,\u201d respectively). The in vivo tests indicated non\u2010toxicity and hypoglycemic effect of the concentrate, since the blood glucose levels were significantly lower in the zebrafish groups treated with this concentrate in comparison with that of control group. Thus, this study suggests the potential of microfiltered red\u2010purple pitaya concentrate as a promising multifunctional food\u2010derived colorant, exhibiting beneficial biological effects far beyond its attractive color.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Hylocereus polyrhizus<\/jats:italic>\n                      \u00a0(F.A.C. Weber) Britton &amp; Rose has attracted attention as a potential source of natural colorants because of its red\u2010purple skin and flesh color. In addition, this fruit has a range of bioactive compounds, which make it a valuable resource for providing potential health benefits and preventing chronic diseases such as diabetes. In this paper, the microfiltered red\u2010purple pitaya concentrate showed beneficial biological effects far beyond its attractive color. Thus, this product can be considered a promising multifunctional food\u2010derived colorant to use in the food, pharmaceutical, or cosmetics industries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17351","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T23:51:59Z","timestamp":1726617119000},"page":"6759-6773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microfiltered red\u2010purple pitaya concentrate: A promising multifunctional food\u2010derived colorant"],"prefix":"10.1111","volume":"89","author":[{"given":"Fernanda Tayla","family":"de Sousa Silva","sequence":"first","affiliation":[{"name":"Federal Institute of Education, Science and Technology of Cear\u00e1 Limoeiro do Norte Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-7846","authenticated-orcid":false,"given":"Jos\u00e9 Diogo","family":"da Rocha Viana","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima","family":"Gomes da Silva","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"Silvestre da Silva","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Izabel","family":"Florindo Guedes","sequence":"additional","affiliation":[{"name":"State University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"de Lima Rebou\u00e7as","sequence":"additional","affiliation":[{"name":"State University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Apolin\u00e1rio da Silva","sequence":"additional","affiliation":[{"name":"State University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnielle Rodrigues","family":"Coutinho","sequence":"additional","affiliation":[{"name":"State University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Wlisses da Silva","sequence":"additional","affiliation":[{"name":"State University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Claudio","family":"Rodrigues de Souza","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Juliao","family":"Zocolo","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Farley","family":"Herbster Moura","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-6383","authenticated-orcid":false,"given":"Ana Paula","family":"Dion\u00edsio","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105687"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450\u2010023\u201000477\u20105"},{"key":"e_1_2_8_4_1","volume-title":"Official methods of analysis of the Association of Official Analytical Chemists International","author":"AOAC","year":"2005"},{"key":"e_1_2_8_5_1","volume-title":"Official methods and recommended practices of the AOCS","author":"AOCS","year":"2013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010019\u201003659\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030808"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300\u2010011X.3132"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.08.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants9101345"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5455\/SPATULA.20160413015353"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.33448\/RSD\u2010V9I7.5035"},{"key":"e_1_2_8_13_1","unstructured":"Concea. 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