{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:58:37Z","timestamp":1789232317717,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      Ulcerative colitis (UC) is a prevalent inflammatory bowel disease associated with abnormal immune responses to commensal bacteria. The study investigated the effects of synbiotic yacon juice fermented by\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      QS7T (FYJ) on ameliorating UC and modulating gut microbiota in a dextran sodium sulfate (DSS)\u2010induced colitis mouse model. FYJ intervention significantly improved body weight and colon length, reduced the disease activity index and histopathological scores, and effectively alleviated colon tissue damage compared with treatments with\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      QS7T suspension or yacon juice alone. Additionally, DSS\u2010induced colitis led to a significant decrease in occludin mRNA expression and an upregulation of genes encoding pro\u2010inflammatory cytokines, which were normalized by FYJ treatment. These effects were accompanied by a significant inhibition of the TLR4\/MyD88\/NF\u2010\u03baB signaling pathway. Moreover, FYJ treatment reversed DSS\u2010induced alternations in gut community beta diversity and composition. In conclusion, FYJ could reduce intestinal mucosal inflammation, repair colonic mucosa, and improve the physiological status of DSS\u2010induced UC mice, possibly through the regulation of the TLR4\/MyD88\/NF\u2010\u03baB signaling pathway and gut microbiota composition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Application<\/jats:title>\n                    <jats:p>The synbiotic yacon juice significantly restores the DSS\u2010induced imbalance in the intestinal microbiota in mice, thereby preserving mucosal immunity and intestinal barrier integrity. The insights derived from this study are expected to provide a novel perspective on the potential application of synbiotic yacon juice as a functional food agent for treating UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17478","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:39:34Z","timestamp":1741747174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synbiotic yacon juice fermented by\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    QS7T attenuates dextran sodium sulfate\u2010induced ulcerative colitis in mice"],"prefix":"10.1111","volume":"90","author":[{"given":"Gui Zhen","family":"Gong","sequence":"first","affiliation":[{"name":"College of Life Science Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui 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