{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:54:07Z","timestamp":1770530047526,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Cumin, a popular spice, is widely used to treat stomach ailments in Central Asia and Xinjiang, China. Cumin essential oil has been found to effectively treat gastric ulcers, but its pharmacodynamic basis remains unclear. In this study, cumin essential oil was directly separated using column chromatography, and its components were identified through multi\u2010dimensional gas chromatography\u2010mass spectrometry. Finally, the cumin essential oil was fractionated into E1, E2, and E3. The effects of these fractions on gastric ulcers were studied using an anhydrous ethanol\u2010induced rat model. The results indicated that the three fractions decreased ulcer index, gastric fluid pH, and pepsin activity to different extents. They lowered the levels of prostaglandin E2, gastrin, and epidermal growth factor in rat serum. According to an analysis of the above indices, E3 fraction had the best anti\u2010ulcer effect. The detection results of the oxidative stress and inflammatory factors showed that all three fractions relieved the ethanol\u2010induced oxidative stress and reduced the release of inflammatory factors to varying degrees. The E3 fraction played the most significant role. The E3 fraction was selected to explore the relevant mechanism, and the results showed that E3 fraction significantly prevented the cleaved caspase\u20103 and Bax protein levels that were ethanol\u2010induced and resisted apoptosis induced by ethanol injury. The western blot results for detecting the NF\u2010\u03baB\u2010related pathway protein showed that E3 fraction significantly inhibited the activation of p\u2010p65, p\u2010IKK\u03b2, and p\u2010I\u03baB\u03b1. The study found that the E3 fraction of cumin essential oil had the most effective anti\u2010ulcer effect by inhibiting NF\u2010\u03baB activation and apoptosis, thus reducing inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17572","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T22:15:36Z","timestamp":1734473736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The therapeutic effect of different cumin essential oil fractions against gastric ulcer in rats"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-5032","authenticated-orcid":false,"given":"Shuai","family":"Lu","sequence":"first","affiliation":[{"name":"Department of emergency The Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Biology, School of Basic Medical Science Guizhou Medical University  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiya","family":"Suo","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Xinjiang University  Urumchi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology, School of Basic Medical Sciences Guizhou Medical University  Guiyang China"},{"name":"Department of Human Anatomy, School of Basic Medical Science Guizhou Medical University  Guiyang Guizhou China"},{"name":"Key Laboratory of Human Brain bank for Functions and Diseases of Department of Education of Guizhou Province Guizhou Medical University  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of emergency The Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020807"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2022.2098107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.697879"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015486"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14040755"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.09.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010199920060\u201000006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2022.2071449"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117793"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105279"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092381"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S436653"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20406"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.11.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001769\u20100"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c04317"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112786"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2020.06.019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14318"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2023.59.2.115"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13102776"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11111178"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10070818"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15051172"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1337785"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030607"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110335"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2019.14028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10\u201016GFR"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529950172772"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115636"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.06.007"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114510"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071476"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102924"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010318715"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo00099k"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002651"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.17572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:41:30Z","timestamp":1762191690000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.17572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/1750-3841.17572"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.17572","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17572"}}