{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:06:07Z","timestamp":1780697167906,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      In the present study, we succeeded in extracting tea polysaccharide (TPS) from\n                      <jats:italic>Tieguanyin<\/jats:italic>\n                      oolong tea, and the TPS was characterized. TPS is an acidic heteropolysaccharide containing rhamnose, arabinose, galactose, glucose (Glc), xylose, mannose, galacturonic acid, and guluronic acid. We found that TPS supplementation partially reversed the elevated levels of serum alanine aminotransferase, total cholesterol, and low\u2010density lipoprotein cholesterol in high\u2010fat diet (HD)\u2010induced nonalcoholic fatty liver disease (NAFLD) mice (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05), and hepatic steatosis and impaired Glc tolerance were also ameliorated. After HD intervention, the activity of Adenosine 5'\u2010monophosphate\u2010activated protein kinase (AMPK) and its downstream genes, including Sirtuin 1 (SIRT1), sterol regulatory element\u2010binding protein\u20101c (SREBP1c), acetyl\u2010coenzyme A carboxylase 1 (ACC1), and adipose triglyceride lipase (ATGL), was significantly inhibited (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). TPS can increase the expression of these genes. The hepatoprotective effects of TPS in AMPK\u2212\/\u2212 mice almost completely disappeared. Moreover, the expression levels of SIRT1, SREBP1c, ACC1, and ATGL did not significantly change after TPS supplementation (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &gt;\u00a00.05). Therefore, our findings suggest that TPS protects the liver from hepatic glucolipid metabolism disorders in HD\u2010induced NAFLD mice by activating AMPK\u2010mediated signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17575","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:09:34Z","timestamp":1733404174000},"page":"10064-10078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of tea polysaccharides from\n                    <i>Ti<\/i>\n                    <i>eguanyin<\/i>\n                    oolong tea and their hepatoprotective effects via AMP\u2010activated protein kinase\u2013mediated signaling pathways"],"prefix":"10.1111","volume":"89","author":[{"given":"Yiqin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Health Inspection and Quarantine School of Public Health 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