{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:17:27Z","timestamp":1789787847453,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Radiation exposure can lead to reproductive damage (RD), for which there is currently no effective treatment. Natural compounds, particularly fungal polysaccharides, have shown promising therapeutic potential for RD. Due to limited availability of effective polysaccharides, research has turned to alternative sources from edible mushrooms. This study evaluated polysaccharides from\n                      <jats:italic>Pleurotus eryngii<\/jats:italic>\n                      ,\n                      <jats:italic>Agaricus bisporus<\/jats:italic>\n                      ,\n                      <jats:italic>Coprinus comatus<\/jats:italic>\n                      , and\n                      <jats:italic>Pleurotus citrinopileatus<\/jats:italic>\n                      for their effects on male mice subjected to X\u2010ray radiation. Histological analysis demonstrated significant damage to testicular tissue following X\u2010ray exposure, alongside altered antioxidant markers, such as malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH\u2010Px). Blood tests revealed mild leukopenia, erythropenia, and thrombocytopenia. Notably, the positive control groups treated with\n                      <jats:italic>A. bisporus<\/jats:italic>\n                      polysaccharides (ABPs) and\n                      <jats:italic>Pleurotus eryngii<\/jats:italic>\n                      polysaccharides showed increased SOD and GSH\u2010Px levels by 46.5% and 7.3%, and 15.9% and 10.1%, respectively, compared to the untreated group. MDA levels were reduced by 62.4% with ABP and by 32.1% with\n                      <jats:italic>Coprinus comatus<\/jats:italic>\n                      polysaccharides. ABPs were the most effective, significantly enhancing WBC, RBC, hemoglobin, and platelets by 58.3%, 8.9%, 30.6%, and 24.6%, respectively. These findings highlight the potential of polysaccharides from edible fungi as natural therapeutic agents for mitigating radiation\u2010induced reproductive damage. Future research on such compounds may pave the way for effective RD treatments.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.17679","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:52:06Z","timestamp":1737939126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of natural polysaccharides from edible mushrooms for the treatment of male testicular injury caused by X\u2010ray"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7491-2430","authenticated-orcid":false,"given":"Nan","family":"Jiang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi of Ministry of Education Jilin Agricultural University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi of Ministry of Education Jilin Agricultural University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi of Ministry of Education Jilin Agricultural University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qi","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi of Ministry of Education Jilin Agricultural University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtian","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi of Ministry of Education Jilin Agricultural University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cofs.2024.101191"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2011.07.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i7.24"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115191"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.11.163"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.2017024486"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.34297\/ajbsr.2020.07.001205"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.25926.1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244\u2010015\u20100410\u20104"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.05.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0840\u20104704(10)60141\u2010X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117081"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.pjz\/20201020051009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2017.12.024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2009.12.003"},{"key":"e_1_2_10_17_1","first-page":"70","article-title":"Environmental assessment of Hefei Binhu national forest park based on LCA","volume":"40","author":"Jiang X. Y.","year":"2023","journal-title":"Journal of Hefei University(Comprehensive Edition)"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12\u20106\u2010738"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13979"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411\u2010020\u201000890\u20107"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.12.122"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133719"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.204"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004447\u20102"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103831"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102017\u20100459"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.12.142"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000326333.42287.a2"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.08.005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2020.02.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755\u20101315\/948\/1\/012078"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113238"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117594"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.962"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1666104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21889"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.2022046311"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.101645"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/273435"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108520"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1179749"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.783884"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.109051"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2024.152300"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.26599\/fshw.2022.9250034"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130173"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2022.07.052"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.01.067"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrras.2024.100872"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.119577"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.17679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:42:21Z","timestamp":1762191741000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.17679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/1750-3841.17679"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.17679","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17679"}}