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BSP and SBSP were administered to mice in the black soybean peptide prevention (BSP\u2010P) group and sprouting black soybean peptide prevention (SBSP\u2010P) group starting 4 weeks prior to the high\u2010salt diet, respectively. Mice in the black soybean peptide intervention (BSP\u2010I) group and the sprouting black soybean peptide intervention (SBSP\u2010I) group received oral doses of BSP and SBSP, respectively, together with a high\u2010salt diet. The findings demonstrated that BSP\u2010I, BSP\u2010P, SBSP\u2010I, and SBSP\u2010P prevented the activation of localized angiotensin converting enzyme (ACE)\/angiotensin II (Ang II) pathways in the kidneys and circulation, delayed the rise in blood pressure in mice, and preserved the functional nitric oxide\/endothelin\u20101 (NO\/ET\u20101) balance of endothelium. The inflammatory factors tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interferon\u2010\u03b3 (IFN\u2010\u03b3), and interleukin\u20106 (IL\u20106) had decreased plasma levels. Additionally, it improved fibrosis, renal edema phenomena, and cardiomegaly. Furthermore, the expression of genes related to the renin\u2013angiotensin system and endothelial function is regulated by SBSP and BSP. On the other hand, compared to intervention effects, SBSP and BSP showed more noticeable preventive benefits on hypertension brought on by a high\u2010salt diet. When all else was equal, SBSP was more effective than BSP at avoiding hypertension. As a result, this study offers theoretical backing for SBSP as a dietary supplement source for the prevention of high\u2010salt diet\u2010induced hypertension.<\/jats:p>","DOI":"10.1111\/1750-3841.70014","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T22:45:31Z","timestamp":1739832331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preventive efficacy of sprouting black soybean peptides on high\u2010salt diet\u2010induced hypertension in mice"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1527-9701","authenticated-orcid":false,"given":"Dawei","family":"Cheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization of Ministry of Agriculture and Rural Affairs, Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, 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