{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:03:32Z","timestamp":1762189412343,"version":"build-2065373602"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      Methionine restriction (MR) has been found to alleviate the progression of diseases such as cognitive disorders and cancer, but it is not clear whether regulating methionine availability can have a beneficial effect on wheat gluten\u2010induced celiac disease. We aimed to excavate the effects of MR on the celiac toxic effects of p31\u201343 gliadin peptide. In this study, we systematically investigated the effects of MR on p31\u201343 gliadin peptide\u2010induced oxidative damage, the elevation of tissue transglutaminase enzyme activity, the overexpression of inflammatory factors, the increase of permeability, and T\u2010lymphocyte dysfunction by utilizing Caco\u20102 epithelial cells and lymphocytes derived from mouse mesenteric lymph nodes to elucidate the effectiveness of MR. Moreover, the potential mechanism of MR on innate and adaptive immune regulation was explored with the help of\n                      <jats:italic>S<\/jats:italic>\n                      \u2010adenosyl\u2010methionine (SAM), a critical metabolic intermediate in methionine cycle. We discovered that MR effectively suppressed the celiac toxic effects of p31\u201343 gliadin peptide. Furthermore, we illustrated the controlling role of SAM in MR to regulate the toxic effects of gliadin in terms of both gliadin\u2010induced innate and adaptive immune responses and found that SAM could directly affect the effectiveness of MR. This study might offer novel insights for the utilization of MR in celiac disease (such as MR interventions or gluten\u2010free diets with specific methionine content) as well as the roles of SAM in MR.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70234","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:00:31Z","timestamp":1745640031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Amelioration of Methionine Restriction on the Celiac Toxic Effects of p31\u201343 Gliadin Peptide Is Disrupted by\n                    <i>S<\/i>\n                    \u2010Adenosyl\u2010Methionine"],"prefix":"10.1111","volume":"90","author":[{"given":"Tian","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Nanchang University  Nanchang Jiangxi China"},{"name":"School of Food Science and 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